FLCN

folliculin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
in utero embryonic development [GO:0001701],
regulation of protein phosphorylation [GO:0001932],
positive regulation of protein phosphorylation [GO:0001934],
cell-cell junction assembly [GO:0007043],
cellular response to starvation [GO:0009267],
positive regulation of autophagy [GO:0010508],
negative regulation of gene expression [GO:0010629],
negative regulation of mitochondrion organization [GO:0010823],
hemopoiesis [GO:0030097],
negative regulation of cell growth [GO:0030308],
negative regulation of cell migration [GO:0030336],
positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511],
TOR signaling [GO:0031929],
regulation of TOR signaling [GO:0032006],
negative regulation of TOR signaling [GO:0032007],
positive regulation of TOR signaling [GO:0032008],
lysosome localization [GO:0032418],
regulation of cytokinesis [GO:0032465],
cellular response to amino acid starvation [GO:0034198],
negative regulation of Rho protein signal transduction [GO:0035024],
regulation of histone acetylation [GO:0035065],
positive regulation of apoptotic process [GO:0043065],
positive regulation of GTPase activity [GO:0043547],
positive regulation of cell adhesion [GO:0045785],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
regulation of Ras protein signal transduction [GO:0046578],
negative regulation of protein kinase B signaling [GO:0051898],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
energy homeostasis [GO:0097009],
negative regulation of protein localization to nucleus [GO:1900181],
negative regulation of cell proliferation involved in kidney development [GO:1901723],
negative regulation of cellular respiration [GO:1901856],
negative regulation of mitochondrial DNA metabolic process [GO:1901859],
negative regulation of muscle tissue development [GO:1901862],
negative regulation of post-translational protein modification [GO:1901874],
negative regulation of brown fat cell differentiation [GO:1903444],
positive regulation of TORC1 signaling [GO:1904263],
regulation of pro-B cell differentiation [GO:2000973],
negative regulation of ATP biosynthetic process [GO:2001170],
positive regulation of intrinsic apoptotic signaling pathway [GO:2001244],
negative regulation of angiogenesis [GO:0016525],
negative regulation of transcription, DNA-templated [GO:0045892],
negative regulation of TORC2 signaling [GO:1903940],

Molecular Function:
guanyl-nucleotide exchange factor activity [GO:0005085],
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
macromolecular complex binding [GO:0044877],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
lysosome [GO:0005764],
lysosomal membrane [GO:0005765],
centrosome [GO:0005813],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cilium [GO:0005929],
midbody [GO:0030496],
cell-cell contact zone [GO:0044291],
mitotic spindle [GO:0072686],
cytoskeleton [GO:0005856],
membrane [GO:0016020],
cell projection [GO:0042995],