FGFR4

fibroblast growth factor receptor 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES
31578521 BJ, hTERT-RPE1, Hep 3B, Huh-7 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
multicellular organism development [GO:0007275],
positive regulation of cell proliferation [GO:0008284],
fibroblast growth factor receptor signaling pathway [GO:0008543],
positive regulation of gene expression [GO:0010628],
regulation of extracellular matrix disassembly [GO:0010715],
cell migration [GO:0016477],
peptidyl-tyrosine phosphorylation [GO:0018108],
regulation of lipid metabolic process [GO:0019216],
positive regulation of kinase activity [GO:0033674],
glucose homeostasis [GO:0042593],
cholesterol homeostasis [GO:0042632],
positive regulation of catalytic activity [GO:0043085],
positive regulation of proteolysis [GO:0045862],
protein autophosphorylation [GO:0046777],
positive regulation of protein kinase B signaling [GO:0051897],
phosphate ion homeostasis [GO:0055062],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
regulation of bile acid biosynthetic process [GO:0070857],
response to bile acid [GO:1903412],
positive regulation of DNA biosynthetic process [GO:2000573],
organ induction [GO:0001759],
protein phosphorylation [GO:0006468],
negative regulation of gene expression [GO:0010629],
regulation of phosphate transport [GO:0010966],
phosphorylation [GO:0016310],
lung development [GO:0030324],
regulation of phosphorus metabolic process [GO:0051174],
alveolar secondary septum development [GO:0061144],
vitamin D3 metabolic process [GO:0070640],
negative regulation of fibroblast growth factor production [GO:0090272],
positive regulation of parathyroid hormone secretion [GO:2000830],

Molecular Function:
transmembrane receptor protein tyrosine kinase activity [GO:0004714],
fibroblast growth factor-activated receptor activity [GO:0005007],
protein binding [GO:0005515],
ATP binding [GO:0005524],
heparin binding [GO:0008201],
fibroblast growth factor binding [GO:0017134],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
protein tyrosine kinase activity [GO:0004713],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
extracellular region [GO:0005576],
endosome [GO:0005768],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell-cell junction [GO:0005911],
transport vesicle [GO:0030133],
receptor complex [GO:0043235],
membrane [GO:0016020],
integral component of membrane [GO:0016021],