FGFR2

fibroblast growth factor receptor 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
19403560 MEF, IMR-90 Human, Mouse NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
MAPK cascade [GO:0000165],
angiogenesis [GO:0001525],
ureteric bud development [GO:0001657],
in utero embryonic development [GO:0001701],
epithelial to mesenchymal transition [GO:0001837],
positive regulation of mesenchymal cell proliferation [GO:0002053],
outflow tract septum morphogenesis [GO:0003148],
membranous septum morphogenesis [GO:0003149],
endochondral bone growth [GO:0003416],
apoptotic process [GO:0006915],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
cell-cell signaling [GO:0007267],
multicellular organism development [GO:0007275],
axonogenesis [GO:0007409],
positive regulation of cell proliferation [GO:0008284],
fibroblast growth factor receptor signaling pathway [GO:0008543],
regulation of smoothened signaling pathway [GO:0008589],
post-embryonic development [GO:0009791],
embryonic pattern specification [GO:0009880],
animal organ morphogenesis [GO:0009887],
positive regulation of phospholipase activity [GO:0010518],
negative regulation of keratinocyte proliferation [GO:0010839],
morphogenesis of embryonic epithelium [GO:0016331],
peptidyl-tyrosine phosphorylation [GO:0018108],
orbitofrontal cortex development [GO:0021769],
ventricular zone neuroblast division [GO:0021847],
pyramidal neuron development [GO:0021860],
gland morphogenesis [GO:0022612],
positive regulation of Wnt signaling pathway [GO:0030177],
bone mineralization [GO:0030282],
lung development [GO:0030324],
epithelial cell differentiation [GO:0030855],
midbrain development [GO:0030901],
otic vesicle formation [GO:0030916],
hair follicle morphogenesis [GO:0031069],
response to lipopolysaccharide [GO:0032496],
lacrimal gland development [GO:0032808],
positive regulation of kinase activity [GO:0033674],
regulation of osteoblast proliferation [GO:0033688],
organ growth [GO:0035265],
fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow [GO:0035602],
fibroblast growth factor receptor signaling pathway involved in hemopoiesis [GO:0035603],
fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow [GO:0035604],
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [GO:0035607],
wound healing [GO:0042060],
inner ear morphogenesis [GO:0042472],
odontogenesis [GO:0042476],
positive regulation of MAPK cascade [GO:0043410],
cell fate commitment [GO:0045165],
response to ethanol [GO:0045471],
regulation of osteoblast differentiation [GO:0045667],
positive regulation of cell cycle [GO:0045787],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
protein autophosphorylation [GO:0046777],
lung alveolus development [GO:0048286],
mesodermal cell differentiation [GO:0048333],
embryonic digestive tract morphogenesis [GO:0048557],
embryonic organ morphogenesis [GO:0048562],
digestive tract development [GO:0048565],
embryonic organ development [GO:0048568],
reproductive structure development [GO:0048608],
positive regulation of smooth muscle cell proliferation [GO:0048661],
embryonic cranial skeleton morphogenesis [GO:0048701],
skeletal system morphogenesis [GO:0048705],
epidermis morphogenesis [GO:0048730],
branching morphogenesis of a nerve [GO:0048755],
mesenchymal cell differentiation [GO:0048762],
positive regulation of epithelial cell proliferation [GO:0050679],
regulation of smooth muscle cell differentiation [GO:0051150],
positive regulation of cell division [GO:0051781],
positive regulation of protein kinase B signaling [GO:0051897],
ventricular cardiac muscle tissue morphogenesis [GO:0055010],
positive regulation of cardiac muscle cell proliferation [GO:0060045],
limb bud formation [GO:0060174],
bone development [GO:0060348],
bone morphogenesis [GO:0060349],
branching involved in prostate gland morphogenesis [GO:0060442],
branching involved in salivary gland morphogenesis [GO:0060445],
bud elongation involved in lung branching [GO:0060449],
lung lobe morphogenesis [GO:0060463],
lung-associated mesenchyme development [GO:0060484],
positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501],
prostate gland morphogenesis [GO:0060512],
prostate epithelial cord elongation [GO:0060523],
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527],
squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [GO:0060529],
fibroblast growth factor receptor signaling pathway involved in mammary gland specification [GO:0060595],
lateral sprouting from an epithelium [GO:0060601],
mammary gland bud formation [GO:0060615],
epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664],
branch elongation involved in salivary gland morphogenesis [GO:0060667],
branching involved in labyrinthine layer morphogenesis [GO:0060670],
regulation of morphogenesis of a branching structure [GO:0060688],
mesenchymal cell differentiation involved in lung development [GO:0060915],
mesenchymal cell proliferation involved in lung development [GO:0060916],
regulation of ERK1 and ERK2 cascade [GO:0070372],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to retinoic acid [GO:0071300],
cellular response to transforming growth factor beta stimulus [GO:0071560],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
protein phosphorylation [GO:0006468],
neuromuscular junction development [GO:0007528],
negative regulation of cell proliferation [GO:0008285],
positive regulation of gene expression [GO:0010628],
phosphorylation [GO:0016310],
regulation of cell proliferation [GO:0042127],
negative regulation of mitotic nuclear division [GO:0045839],
synaptic vesicle transport [GO:0048489],
regulation of epithelial cell proliferation [GO:0050678],
negative regulation of epithelial cell proliferation [GO:0050680],
coronal suture morphogenesis [GO:0060365],
epithelial tube branching involved in lung morphogenesis [GO:0060441],
vasculogenesis involved in coronary vascular morphogenesis [GO:0060979],
endodermal digestive tract morphogenesis [GO:0061031],
lens fiber cell development [GO:0070307],

Molecular Function:
protein tyrosine kinase activity [GO:0004713],
transmembrane receptor protein tyrosine kinase activity [GO:0004714],
fibroblast growth factor-activated receptor activity [GO:0005007],
protein binding [GO:0005515],
ATP binding [GO:0005524],
heparin binding [GO:0008201],
fibroblast growth factor binding [GO:0017134],
protein homodimerization activity [GO:0042803],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
identical protein binding [GO:0042802],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell cortex [GO:0005938],
cell surface [GO:0009986],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
cytoplasmic vesicle [GO:0031410],
receptor complex [GO:0043235],
excitatory synapse [GO:0060076],
extracellular region [GO:0005576],