ALKBH2

alkB homolog 2, alpha-ketoglutarate dependent dioxygenase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated
Pubmed ID	Cell line	Tissue	Source	High-throughput
29321003	Primary bronchial epithelial cells derived from lung		Human	YES
31945054	IMR-90		Human	YES
31945125	Primary astrocytes derived from brain		Human	YES

GO terms:

Biological Process:
DNA dealkylation involved in DNA repair [GO:0006307],
oxidative DNA demethylation [GO:0035511],
oxidative demethylation [GO:0070989],
DNA demethylation [GO:0080111],
DNA repair [GO:0006281],
cellular response to DNA damage stimulus [GO:0006974],
oxidation-reduction process [GO:0055114],

Molecular Function:
ferrous iron binding [GO:0008198],
DNA-N1-methyladenine dioxygenase activity [GO:0043734],
cytosine C-5 DNA demethylase activity [GO:0051747],
1-ethyladenine demethylase activity [GO:0103053],
endonuclease activity [GO:0004519],
exonuclease activity [GO:0004527],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [GO:0016706],
metal ion binding [GO:0046872],
dioxygenase activity [GO:0051213],

Cellular Component:
nucleoplasm [GO:0005654],
nucleus [GO:0005634],