FGF2

fibroblast growth factor 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
18676845 Y-1, BALB-3T3 clone A31 Mouse NO
23991123 Y-1, BALB-3T3 clone A31 mouse NO
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
29548335 Saos-2 Human YES
30854802 Primary progenitor cells derived from heart Human NO
30988157 IMR-90 Human YES
31124078 Primary fibroblasts derived from foreskin, G08, G09 Human NO
31148378 MRC-5 Human YES
31155496 Primary β cells derived from pancreas Mouse YES
31183403 IMR-90 Human YES
31186408 OV-90,OV-1369, OV-1946 Human YES
31840944 Primary mesenchymal stem cells derived from adipose tissue Human NO
31945125 Primary astrocytes derived from brain Human YES
32029712 Primary synovial fibroblast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
15247002 HUVEC Human NO
17532297 MEF Mouse NO
28168007 Primary mesenchymal stem cells derived from adipose tissue Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
31542391 Plasma Human NO
32447347 IMR-90 Human NO

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
activation of MAPK activity [GO:0000187],
branching involved in ureteric bud morphogenesis [GO:0001658],
positive regulation of endothelial cell proliferation [GO:0001938],
cell migration involved in sprouting angiogenesis [GO:0002042],
phosphatidylinositol biosynthetic process [GO:0006661],
chemotaxis [GO:0006935],
signal transduction [GO:0007165],
Ras protein signal transduction [GO:0007265],
nervous system development [GO:0007399],
positive regulation of cell proliferation [GO:0008284],
fibroblast growth factor receptor signaling pathway [GO:0008543],
animal organ morphogenesis [GO:0009887],
negative regulation of gene expression [GO:0010629],
negative regulation of fibroblast migration [GO:0010764],
positive regulation of phospholipase C activity [GO:0010863],
growth factor dependent regulation of skeletal muscle satellite cell proliferation [GO:0014843],
cytokine-mediated signaling pathway [GO:0019221],
extracellular matrix organization [GO:0030198],
hyaluronan catabolic process [GO:0030214],
inositol phosphate biosynthetic process [GO:0032958],
somatic stem cell population maintenance [GO:0035019],
paracrine signaling [GO:0038001],
negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037],
wound healing [GO:0042060],
positive regulation of cell fate specification [GO:0042660],
positive regulation of MAP kinase activity [GO:0043406],
positive regulation of MAPK cascade [GO:0043410],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
negative regulation of blood vessel endothelial cell migration [GO:0043537],
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552],
regulation of angiogenesis [GO:0045765],
positive regulation of angiogenesis [GO:0045766],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
embryonic morphogenesis [GO:0048598],
positive chemotaxis [GO:0050918],
release of sequestered calcium ion into cytosol [GO:0051209],
positive regulation of cell division [GO:0051781],
positive regulation of protein kinase B signaling [GO:0051897],
positive regulation of cardiac muscle cell proliferation [GO:0060045],
negative regulation of cell death [GO:0060548],
chondroblast differentiation [GO:0060591],
negative regulation of wound healing [GO:0061045],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
stem cell proliferation [GO:0072089],
regulation of cell migration involved in sprouting angiogenesis [GO:0090049],
positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050],
positive regulation of lens fiber cell differentiation [GO:1902748],
positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895],
regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903587],
positive regulation of sprouting angiogenesis [GO:1903672],
positive regulation of vascular smooth muscle cell proliferation [GO:1904707],
positive regulation of vascular endothelial cell proliferation [GO:1905564],
regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000544],
positive regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000546],
positive regulation of DNA biosynthetic process [GO:2000573],
positive regulation of endothelial cell chemotaxis [GO:2001028],
activation of MAPKK activity [GO:0000186],
angiogenesis [GO:0001525],
organ induction [GO:0001759],
positive regulation of protein phosphorylation [GO:0001934],
multicellular organism development [GO:0007275],
negative regulation of cell proliferation [GO:0008285],
embryo development ending in birth or egg hatching [GO:0009792],
glial cell differentiation [GO:0010001],
positive regulation of endothelial cell migration [GO:0010595],
positive regulation of gene expression [GO:0010628],
substantia nigra development [GO:0021762],
positive regulation of cerebellar granule cell precursor proliferation [GO:0021940],
cell differentiation [GO:0030154],
lung development [GO:0030324],
positive regulation of cell differentiation [GO:0045597],
positive regulation of osteoblast differentiation [GO:0045669],
regulation of retinal cell programmed cell death [GO:0046668],
positive regulation of smooth muscle cell proliferation [GO:0048661],
response to axon injury [GO:0048678],
stem cell development [GO:0048864],
positive regulation of epithelial cell proliferation [GO:0050679],
regulation of cell cycle [GO:0051726],
cardiac muscle cell proliferation [GO:0060038],
corticotropin hormone secreting cell differentiation [GO:0060128],
thyroid-stimulating hormone-secreting cell differentiation [GO:0060129],
mammary gland epithelial cell differentiation [GO:0060644],
angiogenesis involved in coronary vascular morphogenesis [GO:0060978],
positive regulation of canonical Wnt signaling pathway [GO:0090263],

Molecular Function:
fibroblast growth factor receptor binding [GO:0005104],
cytokine activity [GO:0005125],
integrin binding [GO:0005178],
protein binding [GO:0005515],
growth factor activity [GO:0008083],
heparin binding [GO:0008201],
chemokine binding [GO:0019956],
ligand-dependent nuclear receptor transcription coactivator activity [GO:0030374],
chemoattractant activity [GO:0042056],
identical protein binding [GO:0042802],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],