ALKBH1

alkB homolog 1, histone H2A dioxygenase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
in utero embryonic development [GO:0001701],
neuron migration [GO:0001764],
placenta development [GO:0001890],
tRNA wobble cytosine modification [GO:0002101],
DNA repair [GO:0006281],
DNA dealkylation involved in DNA repair [GO:0006307],
regulation of translational initiation [GO:0006446],
regulation of translational elongation [GO:0006448],
neuron projection development [GO:0031175],
oxidative DNA demethylation [GO:0035511],
oxidative RNA demethylation [GO:0035513],
RNA repair [GO:0042245],
negative regulation of neuron apoptotic process [GO:0043524],
developmental growth [GO:0048589],
positive chemotaxis [GO:0050918],
regulation of mitochondrial translation [GO:0070129],
oxidative demethylation [GO:0070989],
DNA demethylation [GO:0080111],
regulation of gene expression [GO:0010468],
cell differentiation [GO:0030154],

Molecular Function:
tRNA binding [GO:0000049],
ferrous iron binding [GO:0008198],
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [GO:0016706],
oxidative RNA demethylase activity [GO:0035515],
oxidative DNA demethylase activity [GO:0035516],
chemoattractant activity [GO:0042056],
methylcytosine dioxygenase activity [GO:0070579],
1-ethyladenine demethylase activity [GO:0103053],
protein binding [GO:0005515],

Cellular Component:
nucleoplasm [GO:0005654],
nuclear euchromatin [GO:0005719],
mitochondrion [GO:0005739],
endoplasmic reticulum [GO:0005783],