FGF1

fibroblast growth factor 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES
31945054 IMR-90 Human YES

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
activation of MAPK activity [GO:0000187],
angiogenesis [GO:0001525],
organ induction [GO:0001759],
signal transduction [GO:0007165],
multicellular organism development [GO:0007275],
positive regulation of cell proliferation [GO:0008284],
fibroblast growth factor receptor signaling pathway [GO:0008543],
anatomical structure morphogenesis [GO:0009653],
positive regulation of endothelial cell migration [GO:0010595],
cell differentiation [GO:0030154],
lung development [GO:0030324],
positive regulation of cell migration [GO:0030335],
activation of protein kinase B activity [GO:0032148],
cellular response to heat [GO:0034605],
wound healing [GO:0042060],
positive regulation of MAP kinase activity [GO:0043406],
positive regulation of cholesterol biosynthetic process [GO:0045542],
positive regulation of angiogenesis [GO:0045766],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of cell division [GO:0051781],
positive regulation of protein kinase B signaling [GO:0051897],
branch elongation involved in ureteric bud branching [GO:0060681],
mesonephric epithelium development [GO:0072163],
regulation of endothelial tube morphogenesis [GO:1901509],
positive regulation of intracellular signal transduction [GO:1902533],
positive regulation of sprouting angiogenesis [GO:1903672],
positive regulation of hepatocyte proliferation [GO:2000347],
regulation of endothelial cell chemotaxis to fibroblast growth factor [GO:2000544],
positive regulation of protein phosphorylation [GO:0001934],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of epithelial cell proliferation [GO:0050679],
cardiac muscle cell proliferation [GO:0060038],
vasculogenesis involved in coronary vascular morphogenesis [GO:0060979],

Molecular Function:
fibroblast growth factor receptor binding [GO:0005104],
integrin binding [GO:0005178],
protein binding [GO:0005515],
growth factor activity [GO:0008083],
heparin binding [GO:0008201],
Hsp70 protein binding [GO:0030544],
S100 protein binding [GO:0044548],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytosol [GO:0005829],
cell cortex [GO:0005938],
extracellular matrix [GO:0031012],
nucleus [GO:0005634],
cytoplasm [GO:0005737],