FYVE, RhoGEF and PH domain containing 6

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
biological_process [GO:0008150],
regulation of Rho protein signal transduction [GO:0035023],
regulation of GTPase activity [GO:0043087],
cytoskeleton organization [GO:0007010],
regulation of cell shape [GO:0008360],
actin cytoskeleton organization [GO:0030036],
filopodium assembly [GO:0046847],

Molecular Function:
guanyl-nucleotide exchange factor activity [GO:0005085],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
metal ion binding [GO:0046872],
small GTPase binding [GO:0031267],

Cellular Component:
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],
ruffle [GO:0001726],
Golgi apparatus [GO:0005794],
lamellipodium [GO:0030027],