FYVE, RhoGEF and PH domain containing 5

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

GO terms:

Biological Process:
cytoskeleton organization [GO:0007010],
regulation of cell shape [GO:0008360],
actin cytoskeleton organization [GO:0030036],
regulation of GTPase activity [GO:0043087],
filopodium assembly [GO:0046847],
biological_process [GO:0008150],
regulation of Rho protein signal transduction [GO:0035023],

Molecular Function:
guanyl-nucleotide exchange factor activity [GO:0005085],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
protein binding [GO:0005515],
small GTPase binding [GO:0031267],
metal ion binding [GO:0046872],

Cellular Component:
ruffle [GO:0001726],
cytoplasm [GO:0005737],
early endosome [GO:0005769],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
lamellipodium [GO:0030027],
ruffle membrane [GO:0032587],
endosome [GO:0005768],
membrane [GO:0016020],
cell projection [GO:0042995],