FYVE, RhoGEF and PH domain containing 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES

GO terms:

Biological Process:
cytoskeleton organization [GO:0007010],
G-protein coupled receptor signaling pathway [GO:0007186],
regulation of cell shape [GO:0008360],
actin cytoskeleton organization [GO:0030036],
positive regulation of apoptotic process [GO:0043065],
regulation of GTPase activity [GO:0043087],
filopodium assembly [GO:0046847],
regulation of small GTPase mediated signal transduction [GO:0051056],
activation of JUN kinase activity [GO:0007257],
lamellipodium assembly [GO:0030032],
microspike assembly [GO:0030035],
regulation of Rho protein signal transduction [GO:0035023],

Molecular Function:
actin binding [GO:0003779],
guanyl-nucleotide exchange factor activity [GO:0005085],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
small GTPase binding [GO:0031267],
metal ion binding [GO:0046872],
actin filament binding [GO:0051015],

Cellular Component:
ruffle [GO:0001726],
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
lamellipodium [GO:0030027],
filopodium [GO:0030175],
cell projection [GO:0042995],