FYVE, RhoGEF and PH domain containing 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES
30987592 MCF7 Breast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
cytoskeleton organization [GO:0007010],
regulation of Rho protein signal transduction [GO:0035023],
filopodium assembly [GO:0046847],
G-protein coupled receptor signaling pathway [GO:0007186],
regulation of cell shape [GO:0008360],
actin cytoskeleton organization [GO:0030036],
positive regulation of apoptotic process [GO:0043065],
regulation of GTPase activity [GO:0043087],
regulation of small GTPase mediated signal transduction [GO:0051056],

Molecular Function:
guanyl-nucleotide exchange factor activity [GO:0005085],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
metal ion binding [GO:0046872],
small GTPase binding [GO:0031267],

Cellular Component:
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],
ruffle [GO:0001726],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
lamellipodium [GO:0030027],