FER

FER tyrosine kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
microtubule cytoskeleton organization [GO:0000226],
regulation of protein phosphorylation [GO:0001932],
protein phosphorylation [GO:0006468],
chemotaxis [GO:0006935],
cell adhesion [GO:0007155],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
tyrosine phosphorylation of STAT protein [GO:0007260],
cell proliferation [GO:0008283],
positive regulation of cell proliferation [GO:0008284],
regulation of lamellipodium assembly [GO:0010591],
regulation of fibroblast migration [GO:0010762],
peptidyl-tyrosine phosphorylation [GO:0018108],
cytokine-mediated signaling pathway [GO:0019221],
cell differentiation [GO:0030154],
positive regulation of cell migration [GO:0030335],
positive regulation of actin filament polymerization [GO:0030838],
actin cytoskeleton reorganization [GO:0031532],
response to lipopolysaccharide [GO:0032496],
cellular response to insulin stimulus [GO:0032869],
negative regulation of mast cell activation involved in immune response [GO:0033007],
substrate adhesion-dependent cell spreading [GO:0034446],
cellular response to reactive oxygen species [GO:0034614],
extracellular matrix-cell signaling [GO:0035426],
intracellular signal transduction [GO:0035556],
cellular response to macrophage colony-stimulating factor stimulus [GO:0036006],
response to platelet-derived growth factor [GO:0036119],
insulin receptor signaling pathway via phosphatidylinositol 3-kinase [GO:0038028],
peptidyl-tyrosine autophosphorylation [GO:0038083],
Fc-epsilon receptor signaling pathway [GO:0038095],
Kit signaling pathway [GO:0038109],
regulation of epidermal growth factor receptor signaling pathway [GO:0042058],
regulation of cell proliferation [GO:0042127],
regulation of mast cell degranulation [GO:0043304],
cell-cell adhesion mediated by cadherin [GO:0044331],
innate immune response [GO:0045087],
protein autophosphorylation [GO:0046777],
platelet-derived growth factor receptor signaling pathway [GO:0048008],
diapedesis [GO:0050904],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
interleukin-6-mediated signaling pathway [GO:0070102],
signal transduction [GO:0007165],
phosphorylation [GO:0016310],

Molecular Function:
protein tyrosine kinase activity [GO:0004713],
non-membrane spanning protein tyrosine kinase activity [GO:0004715],
receptor binding [GO:0005102],
epidermal growth factor receptor binding [GO:0005154],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein phosphatase 1 binding [GO:0008157],
lipid binding [GO:0008289],
nucleotide binding [GO:0000166],
actin binding [GO:0003779],
protein kinase activity [GO:0004672],
cytoskeletal protein binding [GO:0008092],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
Rab GTPase binding [GO:0017137],
protein kinase binding [GO:0019901],
gamma-catenin binding [GO:0045295],
cadherin binding [GO:0045296],
cell adhesion molecule binding [GO:0050839],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
cell cortex [GO:0005938],
actin cytoskeleton [GO:0015629],
microtubule cytoskeleton [GO:0015630],
lamellipodium [GO:0030027],
cell junction [GO:0030054],
extrinsic component of cytoplasmic side of plasma membrane [GO:0031234],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
membrane [GO:0016020],
cell projection [GO:0042995],