FBXW7

F-box and WD repeat domain containing 7

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
33296652 heart heart Human NO

GO terms:

Biological Process:
vasculogenesis [GO:0001570],
cellular response to DNA damage stimulus [GO:0006974],
sister chromatid cohesion [GO:0007062],
Notch signaling pathway [GO:0007219],
negative regulation of gene expression [GO:0010629],
ubiquitin homeostasis [GO:0010992],
protein ubiquitination [GO:0016567],
lung development [GO:0030324],
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146],
positive regulation of protein ubiquitination [GO:0031398],
protein destabilization [GO:0031648],
cellular response to UV [GO:0034644],
regulation of circadian rhythm [GO:0042752],
proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161],
positive regulation of epidermal growth factor-activated receptor activity [GO:0045741],
rhythmic process [GO:0048511],
protein stabilization [GO:0050821],
positive regulation of ubiquitin-protein transferase activity [GO:0051443],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
regulation of cell migration involved in sprouting angiogenesis [GO:0090049],
positive regulation of proteasomal protein catabolic process [GO:1901800],
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903026],
regulation of mitophagy [GO:1903146],
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378],
positive regulation of protein targeting to mitochondrion [GO:1903955],
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000060],
negative regulation of osteoclast development [GO:2001205],
protein polyubiquitination [GO:0000209],
vasculature development [GO:0001944],
negative regulation of triglyceride biosynthetic process [GO:0010868],
regulation of lipid storage [GO:0010883],
viral process [GO:0016032],
regulation of protein localization [GO:0032880],
post-translational protein modification [GO:0043687],
negative regulation of Notch signaling pathway [GO:0045746],
lipid homeostasis [GO:0055088],
regulation of cell cycle G1/S phase transition [GO:1902806],
negative regulation of hepatocyte proliferation [GO:2000346],
negative regulation of SREBP signaling pathway [GO:2000639],

Molecular Function:
protein binding [GO:0005515],
cyclin binding [GO:0030332],
protein binding, bridging [GO:0030674],
ubiquitin protein ligase binding [GO:0031625],
identical protein binding [GO:0042802],
ubiquitin binding [GO:0043130],
phosphothreonine binding [GO:0050816],
ubiquitin protein ligase activity [GO:0061630],
ubiquitin-protein transferase activator activity [GO:0097027],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
integral component of membrane [GO:0016021],
SCF ubiquitin ligase complex [GO:0019005],
macromolecular complex [GO:0032991],
perinuclear region of cytoplasm [GO:0048471],
Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452],