FAS

Fas cell surface death receptor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21678067 C-85 Human NO
28300842 CRC29, CR16 Human NO
30988157 IMR-90 Human YES
31635416 Primary fibroblasts derived from skin Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
positive regulation of protein phosphorylation [GO:0001934],
apoptotic process [GO:0006915],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
activation-induced cell death of T cells [GO:0006924],
immune response [GO:0006955],
signal transduction [GO:0007165],
regulation of stress-activated MAPK cascade [GO:0032872],
tumor necrosis factor-mediated signaling pathway [GO:0033209],
cellular response to amino acid starvation [GO:0034198],
Fas signaling pathway [GO:0036337],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
macromolecular complex assembly [GO:0065003],
cellular response to mechanical stimulus [GO:0071260],
cellular response to hyperoxia [GO:0071455],
motor neuron apoptotic process [GO:0097049],
apoptotic signaling pathway [GO:0097190],
extrinsic apoptotic signaling pathway [GO:0097191],
extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192],
necroptotic signaling pathway [GO:0097527],
regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041],
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042],
positive regulation of apoptotic signaling pathway [GO:2001235],
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001269],
immunoglobulin production [GO:0002377],
inflammatory cell apoptotic process [GO:0006925],
circadian rhythm [GO:0007623],
extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625],
response to toxic substance [GO:0009636],
gene expression [GO:0010467],
regulation of gene expression [GO:0010468],
negative regulation of Schwann cell proliferation [GO:0010626],
positive regulation of cell death [GO:0010942],
B cell mediated immunity [GO:0019724],
dendrite regeneration [GO:0031104],
positive regulation of protein complex assembly [GO:0031334],
regulation of cell proliferation [GO:0042127],
T cell homeostasis [GO:0043029],
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280],
positive regulation of neuron apoptotic process [GO:0043525],
negative thymic T cell selection [GO:0045060],
regulation of lymphocyte differentiation [GO:0045619],
regulation of myeloid cell differentiation [GO:0045637],
spleen development [GO:0048536],
negative regulation of B cell activation [GO:0050869],
response to glucocorticoid [GO:0051384],
neuron apoptotic process [GO:0051402],
lymphocyte apoptotic process [GO:0070227],
cellular response to lithium ion [GO:0071285],
positive regulation of release of cytochrome c from mitochondria [GO:0090200],
hepatocyte apoptotic process [GO:0097284],
negative regulation of Schwann cell migration [GO:1900148],

Molecular Function:
tumor necrosis factor-activated receptor activity [GO:0005031],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
kinase binding [GO:0019900],
signaling receptor activity [GO:0038023],
identical protein binding [GO:0042802],
protease binding [GO:0002020],
transmembrane signaling receptor activity [GO:0004888],
macromolecular complex binding [GO:0044877],

Cellular Component:
cytosol [GO:0005829],
plasma membrane [GO:0005886],
external side of plasma membrane [GO:0009897],
cell surface [GO:0009986],
integral component of membrane [GO:0016021],
nuclear body [GO:0016604],
death-inducing signaling complex [GO:0031264],
CD95 death-inducing signaling complex [GO:0031265],
membrane raft [GO:0045121],
extracellular exosome [GO:0070062],
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
membrane [GO:0016020],
apical plasma membrane [GO:0016324],
secretory granule [GO:0030141],
sarcolemma [GO:0042383],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
perinuclear region of cytoplasm [GO:0048471],
apical dendrite [GO:0097440],