FERM, ARH/RhoGEF and pleckstrin domain protein 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
synapse assembly [GO:0007416],
negative regulation of phosphatase activity [GO:0010923],
dendrite morphogenesis [GO:0048813],
multicellular organism development [GO:0007275],
regulation of Rho protein signal transduction [GO:0035023],
retrograde trans-synaptic signaling by trans-synaptic protein complex [GO:0098942],
postsynaptic actin cytoskeleton organization [GO:0098974],

Molecular Function:
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
cytoskeletal protein binding [GO:0008092],
Rac guanyl-nucleotide exchange factor activity [GO:0030676],
guanyl-nucleotide exchange factor activity [GO:0005085],
Rac GTPase binding [GO:0048365],

Cellular Component:
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
filopodium [GO:0030175],
dendrite [GO:0030425],
extrinsic component of cytoplasmic side of plasma membrane [GO:0031234],
dendritic spine [GO:0043197],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
membrane [GO:0016020],
cell junction [GO:0030054],
cell projection [GO:0042995],
neuron projection [GO:0043005],
synapse [GO:0045202],
extrinsic component of postsynaptic membrane [GO:0098890],
glutamatergic synapse [GO:0098978],