FANCD2

FA complementation group D2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21995812 Primary fibroblasts derived from skin Foreskin Human NO
23806336 MEF Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29449545 HMEC, MRC-5, IMR-90, GP293, WI-38, HUVEC Human NO
29548335 Saos-2 Human YES
30987592 MCF7 Breast Human YES
30988157 IMR-90 Human YES
31745226 IMR-90, WI-38 Human NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
synapsis [GO:0007129],
gamete generation [GO:0007276],
response to gamma radiation [GO:0010332],
intra-S DNA damage checkpoint [GO:0031573],
cellular response to oxidative stress [GO:0034599],
interstrand cross-link repair [GO:0036297],
regulation of regulatory T cell differentiation [GO:0045589],
brain morphogenesis [GO:0048854],
regulation of inflammatory response [GO:0050727],
regulation of sequence-specific DNA binding transcription factor activity [GO:0051090],
neuronal stem cell population maintenance [GO:0097150],
double-strand break repair involved in meiotic recombination [GO:1990918],
regulation of CD40 signaling pathway [GO:2000348],
DNA repair [GO:0006281],
cellular response to DNA damage stimulus [GO:0006974],
cell cycle [GO:0007049],
multicellular organism development [GO:0007275],

Molecular Function:
protein binding [GO:0005515],
DNA polymerase binding [GO:0070182],

Cellular Component:
condensed chromosome [GO:0000793],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytosol [GO:0005829],
nuclear body [GO:0016604],