FANCD2
FA complementation group D2
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 21995812 | Primary fibroblasts derived from skin | Foreskin | Human | NO |
| 23806336 | MEF | Mouse | NO | |
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 29321003 | Primary bronchial epithelial cells derived from lung | Human | YES | |
| 29449545 | HMEC, MRC-5, IMR-90, GP293, WI-38, HUVEC | Human | NO | |
| 29548335 | Saos-2 | Human | YES | |
| 30987592 | MCF7 | Breast | Human | YES |
| 30988157 | IMR-90 | Human | YES | |
| 31745226 | IMR-90, WI-38 | Human | NO | |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
GO terms:
Biological Process:
synapsis [GO:0007129],
gamete generation [GO:0007276],
response to gamma radiation [GO:0010332],
intra-S DNA damage checkpoint [GO:0031573],
cellular response to oxidative stress [GO:0034599],
interstrand cross-link repair [GO:0036297],
regulation of regulatory T cell differentiation [GO:0045589],
brain morphogenesis [GO:0048854],
regulation of inflammatory response [GO:0050727],
regulation of sequence-specific DNA binding transcription factor activity [GO:0051090],
neuronal stem cell population maintenance [GO:0097150],
double-strand break repair involved in meiotic recombination [GO:1990918],
regulation of CD40 signaling pathway [GO:2000348],
DNA repair [GO:0006281],
cellular response to DNA damage stimulus [GO:0006974],
cell cycle [GO:0007049],
multicellular organism development [GO:0007275],
Molecular Function:
protein binding [GO:0005515],
DNA polymerase binding [GO:0070182],
Cellular Component:
condensed chromosome [GO:0000793],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytosol [GO:0005829],
nuclear body [GO:0016604],