ABCC2

ATP binding cassette subfamily C member 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
response to oxidative stress [GO:0006979],
female pregnancy [GO:0007565],
response to heat [GO:0009408],
negative regulation of gene expression [GO:0010629],
mercury ion transport [GO:0015694],
bile acid and bile salt transport [GO:0015721],
canalicular bile acid transport [GO:0015722],
bilirubin transport [GO:0015723],
prostaglandin transport [GO:0015732],
cellular chloride ion homeostasis [GO:0030644],
response to methotrexate [GO:0031427],
response to estradiol [GO:0032355],
response to glucagon [GO:0033762],
xenobiotic catabolic process [GO:0042178],
response to estrogen [GO:0043627],
response to arsenic-containing substance [GO:0046685],
transmembrane transport [GO:0055085],
thyroid hormone transport [GO:0070327],
transepithelial transport [GO:0070633],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to interleukin-1 [GO:0071347],
cellular response to interleukin-6 [GO:0071354],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to dexamethasone stimulus [GO:0071549],
leukotriene transport [GO:0071716],
benzylpenicillin metabolic process [GO:1901086],
drug transmembrane export [GO:1990961],
drug transport across blood-brain barrier [GO:1990962],
organic anion transport [GO:0015711],
antibiotic metabolic process [GO:0016999],
response to drug [GO:0042493],
detoxification of mercury ion [GO:0050787],

Molecular Function:
protein binding [GO:0005515],
ATP binding [GO:0005524],
organic anion transmembrane transporter activity [GO:0008514],
xenobiotic-transporting ATPase activity [GO:0008559],
bilirubin transmembrane transporter activity [GO:0015127],
ATPase activity [GO:0016887],
protein domain specific binding [GO:0019904],
ATPase activity, coupled to transmembrane movement of substances [GO:0042626],
xenobiotic transporter activity [GO:0042910],

Cellular Component:
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell surface [GO:0009986],
membrane [GO:0016020],
apical plasma membrane [GO:0016324],
brush border membrane [GO:0031526],
intercellular canaliculus [GO:0046581],