ALDH2
aldehyde dehydrogenase 2 family member
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 29321003 | Primary bronchial epithelial cells derived from lung | Human | YES | |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
| 32972203 | heartDPI14 vs healthy | Endothelial cell | Mouse | NO |
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 30315930 | VSMC | Mouse | NO | |
GO terms:
Biological Process:
carbohydrate metabolic process [GO:0005975],
alcohol metabolic process [GO:0006066],
ethanol catabolic process [GO:0006068],
ethanol oxidation [GO:0006069],
electron transport chain [GO:0022900],
acetaldehyde metabolic process [GO:0006117],
intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631],
response to organic cyclic compound [GO:0014070],
negative regulation of apoptotic process [GO:0043066],
behavioral response to ethanol [GO:0048149],
regulation of inflammatory response [GO:0050727],
regulation of reactive oxygen species metabolic process [GO:2000377],
Molecular Function:
aldehyde dehydrogenase (NAD) activity [GO:0004029],
aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030],
electron carrier activity [GO:0009055],
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity [GO:0043878],
NAD binding [GO:0051287],
protein binding [GO:0005515],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620],
identical protein binding [GO:0042802],
NADH binding [GO:0070404],
Cellular Component:
mitochondrial matrix [GO:0005759],
extracellular exosome [GO:0070062],
mitochondrion [GO:0005739],