F2R

coagulation factor II thrombin receptor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

GO terms:

Biological Process:
activation of MAPKK activity [GO:0000186],
connective tissue replacement involved in inflammatory response wound healing [GO:0002248],
negative regulation of glomerular filtration [GO:0003105],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
inflammatory response [GO:0006954],
G-protein coupled receptor signaling pathway [GO:0007186],
phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205],
establishment of synaptic specificity at neuromuscular junction [GO:0007529],
blood coagulation [GO:0007596],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
response to wounding [GO:0009611],
anatomical structure morphogenesis [GO:0009653],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
platelet activation [GO:0030168],
regulation of blood coagulation [GO:0030193],
positive regulation of blood coagulation [GO:0030194],
positive regulation of cell migration [GO:0030335],
response to lipopolysaccharide [GO:0032496],
regulation of interleukin-1 beta production [GO:0032651],
positive regulation of collagen biosynthetic process [GO:0032967],
positive regulation of Rho protein signal transduction [GO:0035025],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280],
positive regulation of MAPK cascade [GO:0043410],
negative regulation of neuron apoptotic process [GO:0043524],
positive regulation of GTPase activity [GO:0043547],
cell-cell junction maintenance [GO:0045217],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of vasoconstriction [GO:0045907],
positive regulation of smooth muscle contraction [GO:0045987],
positive regulation of JAK-STAT cascade [GO:0046427],
homeostasis of number of cells within a tissue [GO:0048873],
release of sequestered calcium ion into cytosol [GO:0051209],
positive regulation of release of sequestered calcium ion into cytosol [GO:0051281],
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482],
positive regulation of calcium ion transport [GO:0051928],
regulation of sensory perception of pain [GO:0051930],
platelet dense granule organization [GO:0060155],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
thrombin-activated receptor signaling pathway [GO:0070493],
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission [GO:0099553],
negative regulation of renin secretion into blood stream [GO:1900134],
positive regulation of interleukin-8 secretion [GO:2000484],
positive regulation of interleukin-6 secretion [GO:2000778],
signal transduction [GO:0007165],
hemostasis [GO:0007599],

Molecular Function:
G-protein alpha-subunit binding [GO:0001965],
G-protein coupled receptor activity [GO:0004930],
receptor binding [GO:0005102],
protein binding [GO:0005515],
thrombin-activated receptor activity [GO:0015057],
G-protein beta-subunit binding [GO:0031681],
heterotrimeric G-protein binding [GO:0032795],

Cellular Component:
extracellular region [GO:0005576],
early endosome [GO:0005769],
late endosome [GO:0005770],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
caveola [GO:0005901],
cell surface [GO:0009986],
platelet dense tubular network [GO:0031094],
neuromuscular junction [GO:0031594],
postsynaptic membrane [GO:0045211],
membrane [GO:0016020],
integral component of membrane [GO:0016021],