F2

coagulation factor II, thrombin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31581517 Primary cells derived form heart Pig NO
31945054 IMR-90 Human YES

GO terms:

Biological Process:
positive regulation of protein phosphorylation [GO:0001934],
proteolysis [GO:0006508],
ER to Golgi vesicle-mediated transport [GO:0006888],
acute-phase response [GO:0006953],
cell surface receptor signaling pathway [GO:0007166],
G-protein coupled receptor signaling pathway [GO:0007186],
multicellular organism development [GO:0007275],
blood coagulation [GO:0007596],
blood coagulation, intrinsic pathway [GO:0007597],
positive regulation of cell proliferation [GO:0008284],
regulation of cell shape [GO:0008360],
response to wounding [GO:0009611],
negative regulation of platelet activation [GO:0010544],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
platelet activation [GO:0030168],
regulation of blood coagulation [GO:0030193],
positive regulation of blood coagulation [GO:0030194],
positive regulation of cell growth [GO:0030307],
regulation of complement activation [GO:0030449],
positive regulation of collagen biosynthetic process [GO:0032967],
fibrinolysis [GO:0042730],
cellular protein metabolic process [GO:0044267],
negative regulation of proteolysis [GO:0045861],
positive regulation of JAK-STAT cascade [GO:0046427],
negative regulation of astrocyte differentiation [GO:0048712],
leukocyte migration [GO:0050900],
positive regulation of release of sequestered calcium ion into cytosol [GO:0051281],
regulation of cytosolic calcium ion concentration [GO:0051480],
cytolysis by host of symbiont cells [GO:0051838],
negative regulation of fibrinolysis [GO:0051918],
neutrophil mediated killing of gram-negative bacterium [GO:0070945],
positive regulation of lipid kinase activity [GO:0090218],
negative regulation of cytokine production involved in inflammatory response [GO:1900016],
positive regulation of protein localization to nucleus [GO:1900182],
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway [GO:1900738],
positive regulation of reactive oxygen species metabolic process [GO:2000379],
hemostasis [GO:0007599],
regulation of gene expression [GO:0010468],
thrombin-activated receptor signaling pathway [GO:0070493],

Molecular Function:
lipopolysaccharide binding [GO:0001530],
serine-type endopeptidase activity [GO:0004252],
receptor binding [GO:0005102],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
enzyme activator activity [GO:0008047],
growth factor activity [GO:0008083],
heparin binding [GO:0008201],
thrombospondin receptor activity [GO:0070053],
peptidase activity [GO:0008233],
serine-type peptidase activity [GO:0008236],
hydrolase activity [GO:0016787],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
endoplasmic reticulum lumen [GO:0005788],
Golgi lumen [GO:0005796],
plasma membrane [GO:0005886],
external side of plasma membrane [GO:0009897],
extracellular exosome [GO:0070062],
blood microparticle [GO:0072562],