Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
intestinal D-glucose absorption [GO:0001951],
sphingosine-1-phosphate signaling pathway [GO:0003376],
leukocyte cell-cell adhesion [GO:0007159],
axon guidance [GO:0007411],
regulation of cell shape [GO:0008360],
regulation of cell size [GO:0008361],
positive regulation of gene expression [GO:0010628],
protein kinase A signaling [GO:0010737],
gland morphogenesis [GO:0022612],
membrane to membrane docking [GO:0022614],
microvillus assembly [GO:0030033],
astral microtubule organization [GO:0030953],
actin cytoskeleton reorganization [GO:0031532],
receptor internalization [GO:0031623],
regulation of microvillus length [GO:0032532],
regulation of actin cytoskeleton organization [GO:0032956],
cellular protein complex localization [GO:0034629],
positive regulation of multicellular organism growth [GO:0040018],
cortical microtubule organization [GO:0043622],
establishment of epithelial cell apical/basal polarity [GO:0045198],
filopodium assembly [GO:0046847],
phosphatidylinositol-mediated signaling [GO:0048015],
positive regulation of protein secretion [GO:0050714],
negative regulation of T cell receptor signaling pathway [GO:0050860],
actin filament bundle assembly [GO:0051017],
establishment of centrosome localization [GO:0051660],
establishment of endothelial barrier [GO:0061028],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
cellular response to cAMP [GO:0071320],
protein localization to plasma membrane [GO:0072659],
protein localization to cell cortex [GO:0072697],
negative regulation of interleukin-2 secretion [GO:1900041],
regulation of NIK/NF-kappaB signaling [GO:1901222],
regulation of organelle assembly [GO:1902115],
terminal web assembly [GO:1902896],
positive regulation of protein localization to early endosome [GO:1902966],
positive regulation of protein localization to plasma membrane [GO:1903078],
positive regulation of cellular protein catabolic process [GO:1903364],
negative regulation of p38MAPK cascade [GO:1903753],
positive regulation of early endosome to late endosome transport [GO:2000643],
establishment or maintenance of apical/basal cell polarity [GO:0035088],

Molecular Function:
RNA binding [GO:0003723],
actin binding [GO:0003779],
protein binding [GO:0005515],
microtubule binding [GO:0008017],
protein C-terminus binding [GO:0008022],
protein domain specific binding [GO:0019904],
protein kinase A catalytic subunit binding [GO:0034236],
protein kinase A regulatory subunit binding [GO:0034237],
identical protein binding [GO:0042802],
S100 protein binding [GO:0044548],
cadherin binding [GO:0045296],
cell adhesion molecule binding [GO:0050839],
actin filament binding [GO:0051015],
protein kinase A binding [GO:0051018],
ATPase binding [GO:0051117],
disordered domain specific binding [GO:0097718],
cytoskeletal protein binding [GO:0008092],
macromolecular complex binding [GO:0044877],

Cellular Component:
fibrillar center [GO:0001650],
ruffle [GO:0001726],
immunological synapse [GO:0001772],
uropod [GO:0001931],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
endosome [GO:0005768],
cytosol [GO:0005829],
actin filament [GO:0005884],
plasma membrane [GO:0005886],
microvillus [GO:0005902],
brush border [GO:0005903],
focal adhesion [GO:0005925],
actin cytoskeleton [GO:0015629],
membrane [GO:0016020],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
extrinsic component of membrane [GO:0019898],
filopodium [GO:0030175],
T-tubule [GO:0030315],
cortical cytoskeleton [GO:0030863],
microvillus membrane [GO:0031528],
vesicle [GO:0031982],
ruffle membrane [GO:0032587],
macromolecular complex [GO:0032991],
ciliary basal body [GO:0036064],
cell projection [GO:0042995],
cell body [GO:0044297],
microspike [GO:0044393],
plasma membrane raft [GO:0044853],
apical part of cell [GO:0045177],
perinuclear region of cytoplasm [GO:0048471],
cell tip [GO:0051286],
extracellular exosome [GO:0070062],
invadopodium [GO:0071437],
cell periphery [GO:0071944],
astrocyte projection [GO:0097449],
Schwann cell microvillus [GO:0097454],
cytoplasmic side of apical plasma membrane [GO:0098592],
intracellular [GO:0005622],
cytoskeleton [GO:0005856],
myelin sheath [GO:0043209],
membrane raft [GO:0045121],