EXT1

exostosin glycosyltransferase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
33296652 heart heart Human NO

GO terms:

Biological Process:
skeletal system development [GO:0001501],
ossification [GO:0001503],
glycosaminoglycan biosynthetic process [GO:0006024],
protein glycosylation [GO:0006486],
signal transduction [GO:0007165],
gastrulation [GO:0007369],
axon guidance [GO:0007411],
endoderm development [GO:0007492],
mesoderm development [GO:0007498],
heparan sulfate proteoglycan biosynthetic process [GO:0015012],
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014],
olfactory bulb development [GO:0021772],
cellular polysaccharide biosynthetic process [GO:0033692],
embryonic skeletal joint development [GO:0072498],
cell morphogenesis [GO:0000902],
endochondral ossification [GO:0001958],
blood vessel remodeling [GO:0001974],
chondrocyte differentiation [GO:0002062],
glandular epithelial cell differentiation [GO:0002067],
hypersensitivity [GO:0002524],
heart field specification [GO:0003128],
endochondral bone growth [GO:0003416],
vacuole organization [GO:0007033],
cell adhesion [GO:0007155],
cell surface receptor signaling pathway [GO:0007166],
smoothened signaling pathway [GO:0007224],
brain development [GO:0007420],
regulation of blood pressure [GO:0008217],
cell proliferation [GO:0008283],
fibroblast growth factor receptor signaling pathway [GO:0008543],
response to virus [GO:0009615],
response to light intensity [GO:0009642],
gene expression [GO:0010467],
neural crest cell differentiation [GO:0014033],
cellular component organization [GO:0016043],
stem cell division [GO:0017145],
antigen processing and presentation [GO:0019882],
optic nerve development [GO:0021554],
protein catabolic process [GO:0030163],
proteoglycan biosynthetic process [GO:0030166],
collagen fibril organization [GO:0030199],
heparin metabolic process [GO:0030202],
heparin biosynthetic process [GO:0030210],
BMP signaling pathway [GO:0030509],
neuron projection development [GO:0031175],
chemokine production [GO:0032602],
glomerular basement membrane development [GO:0032836],
cell adhesion mediated by integrin [GO:0033627],
social behavior [GO:0035176],
synaptic transmission, glutamatergic [GO:0035249],
chondrocyte proliferation [GO:0035988],
limb joint morphogenesis [GO:0036022],
dendritic cell migration [GO:0036336],
lymphocyte adhesion to endothelial cell of high endothelial venule [GO:0036339],
fluid transport [GO:0042044],
wound healing [GO:0042060],
vasodilation [GO:0042311],
fear response [GO:0042596],
cellular response to fibroblast growth factor stimulus [GO:0044344],
cell fate commitment [GO:0045165],
multicellular organismal water homeostasis [GO:0050891],
leukocyte tethering or rolling [GO:0050901],
sulfation [GO:0051923],
sodium ion homeostasis [GO:0055078],
heart contraction [GO:0060047],
canonical Wnt signaling pathway [GO:0060070],
hematopoietic stem cell differentiation [GO:0060218],
bone morphogenesis [GO:0060349],
endochondral bone morphogenesis [GO:0060350],
cartilage development involved in endochondral bone morphogenesis [GO:0060351],
epithelium development [GO:0060429],
epithelial tube branching involved in lung morphogenesis [GO:0060441],
mesenchyme development [GO:0060485],
smoothened signaling pathway involved in lung development [GO:0060506],
developmental growth involved in morphogenesis [GO:0060560],
motor behavior [GO:0061744],
macromolecular complex assembly [GO:0065003],
dendrite self-avoidance [GO:0070593],
response to heparin [GO:0071503],
vocalization behavior [GO:0071625],
basement membrane organization [GO:0071711],
cellular response to BMP stimulus [GO:0071773],
glomerular visceral epithelial cell differentiation [GO:0072112],
lymphocyte migration into lymphoid organs [GO:0097021],
bone growth [GO:0098868],
mesenchymal cell differentiation involved in bone development [GO:1901706],
cranial skeletal system development [GO:1904888],
response to leukemia inhibitory factor [GO:1990823],

Molecular Function:
acetylglucosaminyltransferase activity [GO:0008375],
glucuronosyltransferase activity [GO:0015020],
transferase activity, transferring glycosyl groups [GO:0016757],
heparan sulfate N-acetylglucosaminyltransferase activity [GO:0042328],
protein homodimerization activity [GO:0042803],
metal ion binding [GO:0046872],
protein heterodimerization activity [GO:0046982],
glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0050508],
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [GO:0050509],
transferase activity [GO:0016740],

Cellular Component:
Golgi membrane [GO:0000139],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
Golgi apparatus [GO:0005794],
integral component of membrane [GO:0016021],
integral component of endoplasmic reticulum membrane [GO:0030176],
membrane [GO:0016020],