aldehyde dehydrogenase 1 family member A3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29548335 Li Fraumeni Human YES
30626320 HBEC Human NO
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES
32056555 HUVEC Human NO

GO terms:

Biological Process:
optic cup morphogenesis involved in camera-type eye development [GO:0002072],
retinoic acid biosynthetic process [GO:0002138],
locomotory behavior [GO:0007626],
nucleus accumbens development [GO:0021768],
embryonic camera-type eye development [GO:0031076],
inner ear morphogenesis [GO:0042472],
retinol metabolic process [GO:0042572],
retinoic acid metabolic process [GO:0042573],
retinal metabolic process [GO:0042574],
positive regulation of apoptotic process [GO:0043065],
embryonic eye morphogenesis [GO:0048048],
neuromuscular process controlling balance [GO:0050885],
protein homotetramerization [GO:0051289],
oxidation-reduction process [GO:0055114],
righting reflex [GO:0060013],
olfactory pit development [GO:0060166],
face development [GO:0060324],
Harderian gland development [GO:0070384],
cellular aldehyde metabolic process [GO:0006081],
nose development [GO:0043584],
positive regulation of retinoic acid receptor signaling pathway [GO:0048386],

Molecular Function:
retinal dehydrogenase activity [GO:0001758],
aldehyde dehydrogenase (NAD) activity [GO:0004029],
aldehyde dehydrogenase [NAD(P)+] activity [GO:0004030],
protein homodimerization activity [GO:0042803],
thyroid hormone binding [GO:0070324],
NAD+ binding [GO:0070403],
3-chloroallyl aldehyde dehydrogenase activity [GO:0004028],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620],

Cellular Component:
cytoplasm [GO:0005737],
cytosol [GO:0005829],
extracellular exosome [GO:0070062],