aldehyde dehydrogenase 1 family member A2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
33296652 heart heart Human NO

GO terms:

Biological Process:
blood vessel development [GO:0001568],
kidney development [GO:0001822],
liver development [GO:0001889],
regulation of endothelial cell proliferation [GO:0001936],
retinoic acid biosynthetic process [GO:0002138],
heart morphogenesis [GO:0003007],
vitamin A metabolic process [GO:0006776],
midgut development [GO:0007494],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
determination of bilateral symmetry [GO:0009855],
proximal/distal pattern formation [GO:0009954],
positive regulation of gene expression [GO:0010628],
neural crest cell development [GO:0014032],
morphogenesis of embryonic epithelium [GO:0016331],
neural tube development [GO:0021915],
pituitary gland development [GO:0021983],
neuron differentiation [GO:0030182],
lung development [GO:0030324],
hindbrain development [GO:0030902],
pancreas development [GO:0031016],
embryonic camera-type eye development [GO:0031076],
response to estradiol [GO:0032355],
response to vitamin A [GO:0033189],
response to cytokine [GO:0034097],
embryonic forelimb morphogenesis [GO:0035115],
ureter maturation [GO:0035799],
retinol metabolic process [GO:0042572],
retinoic acid metabolic process [GO:0042573],
retinal metabolic process [GO:0042574],
9-cis-retinoic acid biosynthetic process [GO:0042904],
positive regulation of apoptotic process [GO:0043065],
embryonic digestive tract development [GO:0048566],
cardiac muscle tissue development [GO:0048738],
protein homotetramerization [GO:0051289],
oxidation-reduction process [GO:0055114],
face development [GO:0060324],
cellular response to retinoic acid [GO:0071300],
retinoic acid receptor signaling pathway involved in somitogenesis [GO:0090242],
retinoid metabolic process [GO:0001523],
heart looping [GO:0001947],
heart development [GO:0007507],
anterior/posterior pattern specification [GO:0009952],
embryonic limb morphogenesis [GO:0030326],
forebrain development [GO:0030900],
camera-type eye development [GO:0043010],
retinoic acid receptor signaling pathway [GO:0048384],

Molecular Function:
retinal dehydrogenase activity [GO:0001758],
3-chloroallyl aldehyde dehydrogenase activity [GO:0004028],
aldehyde dehydrogenase (NAD) activity [GO:0004029],
retinal binding [GO:0016918],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [GO:0016620],

Cellular Component:
cytoplasm [GO:0005737],
cytosol [GO:0005829],
perinuclear region of cytoplasm [GO:0048471],