ESR2

estrogen receptor 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29030963 Primary stromal cells derived from bone marrow Rat NO
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
regulation of transcription, DNA-templated [GO:0006355],
transcription initiation from RNA polymerase II promoter [GO:0006367],
signal transduction [GO:0007165],
cell-cell signaling [GO:0007267],
negative regulation of cell growth [GO:0030308],
intracellular estrogen receptor signaling pathway [GO:0030520],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
negative regulation of receptor activity [GO:2000272],
ovarian follicle development [GO:0001541],
behavioral fear response [GO:0001662],
neuron migration [GO:0001764],
brain development [GO:0007420],
learning or memory [GO:0007611],
negative regulation of cell proliferation [GO:0008285],
hormone-mediated apoptotic signaling pathway [GO:0008628],
intracellular steroid hormone receptor signaling pathway [GO:0030518],
response to testosterone [GO:0033574],
regulation of cell proliferation [GO:0042127],
positive regulation of apoptotic process [GO:0043065],
regulation of neuron apoptotic process [GO:0043523],
estrous cycle [GO:0044849],
positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
negative regulation of behavior [GO:0048521],
negative regulation of smooth muscle cell proliferation [GO:0048662],
negative regulation of epithelial cell proliferation [GO:0050680],
Sertoli cell proliferation [GO:0060011],
uterus development [GO:0060065],
vagina development [GO:0060068],
negative regulation of cell death [GO:0060548],
prostate gland epithelium morphogenesis [GO:0060740],
epithelial cell maturation involved in prostate gland development [GO:0060743],
negative regulation of androgen receptor signaling pathway [GO:0060766],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to estradiol stimulus [GO:0071392],
negative regulation of neuron death [GO:1901215],
negative regulation of feeding behavior [GO:2000252],
negative regulation of reactive oxygen species metabolic process [GO:2000378],

Molecular Function:
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
DNA binding [GO:0003677],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
steroid hormone receptor activity [GO:0003707],
transcription coactivator activity [GO:0003713],
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding [GO:0004879],
steroid binding [GO:0005496],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
enzyme binding [GO:0019899],
estrogen receptor activity [GO:0030284],
estrogen response element binding [GO:0034056],
identical protein binding [GO:0042802],
receptor antagonist activity [GO:0048019],
repressing transcription factor binding [GO:0070491],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
drug binding [GO:0008144],
lipid binding [GO:0008289],
hormone binding [GO:0042562],
peroxisome proliferator activated receptor binding [GO:0042975],
sequence-specific DNA binding [GO:0043565],
metal ion binding [GO:0046872],
estradiol binding [GO:1903924],
steroid hormone binding [GO:1990239],
promoter-specific chromatin binding [GO:1990841],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
mitochondrion [GO:0005739],
host cell nucleus [GO:0042025],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
cilium [GO:0005929],
protein-DNA complex [GO:0032993],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
perikaryon [GO:0043204],
perinuclear region of cytoplasm [GO:0048471],