erb-b2 receptor tyrosine kinase 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES
30988157 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29524631 MG63.2, Saos-2 Human NO

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
neural crest cell migration [GO:0001755],
positive regulation of protein phosphorylation [GO:0001934],
signal transduction [GO:0007165],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
multicellular organism development [GO:0007275],
nervous system development [GO:0007399],
synapse assembly [GO:0007416],
heart development [GO:0007507],
lactation [GO:0007595],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
embryonic pattern specification [GO:0009880],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
cell migration [GO:0016477],
peptidyl-tyrosine phosphorylation [GO:0018108],
central nervous system morphogenesis [GO:0021551],
olfactory bulb interneuron differentiation [GO:0021889],
regulation of cell migration [GO:0030334],
positive regulation of kinase activity [GO:0033674],
ERBB2 signaling pathway [GO:0038128],
positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531],
mitochondrial fragmentation involved in apoptotic process [GO:0043653],
cell fate commitment [GO:0045165],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of JAK-STAT cascade [GO:0046427],
protein autophosphorylation [GO:0046777],
positive regulation of protein kinase B signaling [GO:0051897],
positive regulation of cardiac muscle cell proliferation [GO:0060045],
mammary gland epithelial cell differentiation [GO:0060644],
mammary gland alveolus development [GO:0060749],
cardiac muscle tissue regeneration [GO:0061026],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to epidermal growth factor stimulus [GO:0071364],
positive regulation of protein localization to cell surface [GO:2000010],
regulation of cell motility [GO:2000145],
negative regulation of neuron migration [GO:2001223],
protein phosphorylation [GO:0006468],
apoptotic process [GO:0006915],
negative regulation of muscle cell apoptotic process [GO:0010656],
phosphorylation [GO:0016310],
positive regulation of cell migration [GO:0030335],
positive regulation of synaptic transmission, GABAergic [GO:0032230],
peptidyl-tyrosine autophosphorylation [GO:0038083],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
surfactant homeostasis [GO:0043129],
positive regulation of glucose import [GO:0046326],
positive regulation of epithelial cell proliferation [GO:0050679],
synapse maturation [GO:0060074],
establishment of planar polarity involved in nephron morphogenesis [GO:0072046],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
protein tyrosine kinase activity [GO:0004713],
transmembrane receptor protein tyrosine kinase activity [GO:0004714],
epidermal growth factor receptor binding [GO:0005154],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein homodimerization activity [GO:0042803],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
neuregulin binding [GO:0038132],

Cellular Component:
extracellular region [GO:0005576],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
mitochondrion [GO:0005739],
mitochondrial matrix [GO:0005759],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
basal plasma membrane [GO:0009925],
basolateral plasma membrane [GO:0016323],
receptor complex [GO:0043235],
postsynaptic membrane [GO:0045211],
glutamatergic synapse [GO:0098978],
GABA-ergic synapse [GO:0098982],
integral component of presynaptic membrane [GO:0099056],
integral component of postsynaptic density membrane [GO:0099061],
cytoplasm [GO:0005737],
caveola [GO:0005901],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
membrane raft [GO:0045121],