ERBB2

erb-b2 receptor tyrosine kinase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
15705882 MCF7, MEF Human, mouse NO
21297664 MCF 1A Human NO
23288917 MCF-7, T-47D Mouse NO
26260680 MCF 1A, MCF7 Human NO
29548335 Saos-2 Human YES
30458137 MCF 1A Human NO
31219154 MCF10A Breast Human,Mouse NO
31945125 Primary astrocytes derived from brain Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
positive regulation of protein phosphorylation [GO:0001934],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
protein phosphorylation [GO:0006468],
signal transduction [GO:0007165],
cell surface receptor signaling pathway [GO:0007166],
enzyme linked receptor protein signaling pathway [GO:0007167],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
multicellular organism development [GO:0007275],
peripheral nervous system development [GO:0007422],
heart development [GO:0007507],
neuromuscular junction development [GO:0007528],
motor neuron axon guidance [GO:0008045],
positive regulation of cell proliferation [GO:0008284],
phosphatidylinositol 3-kinase signaling [GO:0014065],
peptidyl-tyrosine phosphorylation [GO:0018108],
neuron differentiation [GO:0030182],
positive regulation of cell growth [GO:0030307],
regulation of microtubule-based process [GO:0032886],
negative regulation of immature T cell proliferation in thymus [GO:0033088],
positive regulation of kinase activity [GO:0033674],
intracellular signal transduction [GO:0035556],
ERBB2 signaling pathway [GO:0038128],
wound healing [GO:0042060],
myelination [GO:0042552],
positive regulation of MAP kinase activity [GO:0043406],
positive regulation of MAPK cascade [GO:0043410],
positive regulation of GTPase activity [GO:0043547],
positive regulation of translation [GO:0045727],
regulation of angiogenesis [GO:0045765],
positive regulation of cell adhesion [GO:0045785],
positive regulation of transcription from RNA polymerase I promoter [GO:0045943],
protein autophosphorylation [GO:0046777],
oligodendrocyte differentiation [GO:0048709],
positive regulation of epithelial cell proliferation [GO:0050679],
positive regulation of protein kinase B signaling [GO:0051897],
regulation of ERK1 and ERK2 cascade [GO:0070372],
cellular response to growth factor stimulus [GO:0071363],
cellular response to epidermal growth factor stimulus [GO:0071364],
positive regulation of protein targeting to membrane [GO:0090314],
negative regulation of ERBB signaling pathway [GO:1901185],
regulation of cell motility [GO:2000145],
nervous system development [GO:0007399],
glial cell differentiation [GO:0010001],
positive regulation of gene expression [GO:0010628],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
phosphorylation [GO:0016310],
negative regulation of apoptotic process [GO:0043066],
estrous cycle [GO:0044849],
positive regulation of Ras protein signal transduction [GO:0046579],
sympathetic nervous system development [GO:0048485],
response to axon injury [GO:0048678],

Molecular Function:
RNA polymerase I core binding [GO:0001042],
protein tyrosine kinase activity [GO:0004713],
transmembrane receptor protein tyrosine kinase activity [GO:0004714],
transmembrane signaling receptor activity [GO:0004888],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein C-terminus binding [GO:0008022],
growth factor binding [GO:0019838],
protein phosphatase binding [GO:0019903],
identical protein binding [GO:0042802],
ErbB-3 class receptor binding [GO:0043125],
protein heterodimerization activity [GO:0046982],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
ubiquitin protein ligase binding [GO:0031625],
macromolecular complex binding [GO:0044877],
Hsp90 protein binding [GO:0051879],

Cellular Component:
nucleus [GO:0005634],
early endosome [GO:0005769],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
basal plasma membrane [GO:0009925],
endosome membrane [GO:0010008],
integral component of membrane [GO:0016021],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
ERBB3:ERBB2 complex [GO:0038143],
myelin sheath [GO:0043209],
receptor complex [GO:0043235],
perinuclear region of cytoplasm [GO:0048471],
cytoplasm [GO:0005737],
endosome [GO:0005768],
microvillus [GO:0005902],
membrane [GO:0016020],
cytoplasmic vesicle [GO:0031410],
lateral loop [GO:0043219],
membrane raft [GO:0045121],
postsynaptic membrane [GO:0045211],