ERAP2

endoplasmic reticulum aminopeptidase 2

Link to human ortholog


Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
adaptive immune response [GO:0002250],
antigen processing and presentation of peptide antigen via MHC class I [GO:0002474],
proteolysis [GO:0006508],
regulation of blood pressure [GO:0008217],
antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885],
peptide catabolic process [GO:0043171],

Molecular Function:
aminopeptidase activity [GO:0004177],
metallopeptidase activity [GO:0008237],
zinc ion binding [GO:0008270],
peptide binding [GO:0042277],
metalloaminopeptidase activity [GO:0070006],

Cellular Component:
cytoplasm [GO:0005737],
endoplasmic reticulum lumen [GO:0005788],
endoplasmic reticulum membrane [GO:0005789],
plasma membrane [GO:0005886],
integral component of membrane [GO:0016021],