ERAP1

endoplasmic reticulum aminopeptidase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
angiogenesis [GO:0001525],
adaptive immune response [GO:0002250],
antigen processing and presentation of peptide antigen via MHC class I [GO:0002474],
proteolysis [GO:0006508],
membrane protein ectodomain proteolysis [GO:0006509],
regulation of blood pressure [GO:0008217],
response to bacterium [GO:0009617],
antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885],
peptide catabolic process [GO:0043171],
regulation of innate immune response [GO:0045088],
fat cell differentiation [GO:0045444],
positive regulation of angiogenesis [GO:0045766],
immune system process [GO:0002376],

Molecular Function:
aminopeptidase activity [GO:0004177],
interleukin-6 receptor binding [GO:0005138],
interleukin-1, Type II receptor binding [GO:0005151],
protein binding [GO:0005515],
metalloexopeptidase activity [GO:0008235],
zinc ion binding [GO:0008270],
peptide binding [GO:0042277],
metalloaminopeptidase activity [GO:0070006],
tumor necrosis factor receptor binding [GO:0005164],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum lumen [GO:0005788],
endoplasmic reticulum membrane [GO:0005789],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
extracellular exosome [GO:0070062],
intracellular membrane-bounded organelle [GO:0043231],