AKT serine/threonine kinase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31527305 A549 Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
33296652 heart heart Human NO

GO terms:

Biological Process:
positive regulation of protein phosphorylation [GO:0001934],
glycogen biosynthetic process [GO:0005978],
glucose metabolic process [GO:0006006],
regulation of translation [GO:0006417],
cellular protein modification process [GO:0006464],
signal transduction [GO:0007165],
positive regulation of cell proliferation [GO:0008284],
insulin receptor signaling pathway [GO:0008286],
carbohydrate transport [GO:0008643],
negative regulation of plasma membrane long-chain fatty acid transport [GO:0010748],
positive regulation of glucose metabolic process [GO:0010907],
positive regulation of mitochondrial membrane potential [GO:0010918],
peptidyl-serine phosphorylation [GO:0018105],
regulation of cell migration [GO:0030334],
positive regulation of cell migration [GO:0030335],
positive regulation of vesicle fusion [GO:0031340],
positive regulation of fatty acid beta-oxidation [GO:0032000],
peripheral nervous system myelin maintenance [GO:0032287],
cellular response to insulin stimulus [GO:0032869],
intracellular signal transduction [GO:0035556],
negative regulation of apoptotic process [GO:0043066],
fat cell differentiation [GO:0045444],
positive regulation of glycogen biosynthetic process [GO:0045725],
positive regulation of glucose import [GO:0046326],
mammary gland epithelial cell differentiation [GO:0060644],
intracellular protein transmembrane transport [GO:0065002],
regulation of cell cycle arrest [GO:0071156],
cellular response to high light intensity [GO:0071486],
protein localization to plasma membrane [GO:0072659],
positive regulation of protein targeting to membrane [GO:0090314],
activation of GTPase activity [GO:0090630],
retinal rod cell apoptotic process [GO:0097473],
positive regulation of cell motility [GO:2000147],
carbohydrate metabolic process [GO:0005975],
glycogen metabolic process [GO:0005977],
protein phosphorylation [GO:0006468],
apoptotic process [GO:0006915],
multicellular organism development [GO:0007275],
positive regulation of signal transduction [GO:0009967],
positive regulation of gene expression [GO:0010628],
positive regulation of sodium ion transport [GO:0010765],
phosphorylation [GO:0016310],
response to insulin [GO:0032868],
negative regulation of RNA splicing [GO:0033119],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
protein kinase B signaling [GO:0043491],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of positive chemotaxis [GO:0050927],
cellular response to organic cyclic compound [GO:0071407],

Molecular Function:
protein serine/threonine kinase activity [GO:0004674],
protein binding [GO:0005515],
ATP binding [GO:0005524],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
protein kinase C binding [GO:0005080],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
early endosome [GO:0005769],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell cortex [GO:0005938],
ruffle membrane [GO:0032587],
macromolecular complex [GO:0032991],
intracellular membrane-bounded organelle [GO:0043231],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
endosome [GO:0005768],
membrane [GO:0016020],
sarcoplasmic reticulum [GO:0016529],
vesicle [GO:0031982],
insulin-responsive compartment [GO:0032593],