EPM2A glucan phosphatase, laforin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
positive regulation of macroautophagy [GO:0016239],
negative regulation of TOR signaling [GO:0032007],
autophagosome assembly [GO:0000045],
regulation of cell growth [GO:0001558],
regulation of protein phosphorylation [GO:0001932],
carbohydrate metabolic process [GO:0005975],
glycogen metabolic process [GO:0005977],
glycogen biosynthetic process [GO:0005978],
protein dephosphorylation [GO:0006470],
calcium ion transport [GO:0006816],
autophagy [GO:0006914],
mitochondrion organization [GO:0007005],
nervous system development [GO:0007399],
regulation of gene expression [GO:0010468],
negative regulation of gene expression [GO:0010629],
negative regulation of phosphatase activity [GO:0010923],
glial cell proliferation [GO:0014009],
L-glutamate transport [GO:0015813],
Wnt signaling pathway [GO:0016055],
dephosphorylation [GO:0016311],
regulation of protein ubiquitination [GO:0031396],
negative regulation of peptidyl-serine phosphorylation [GO:0033137],
negative regulation of dephosphorylation [GO:0035305],
peptidyl-tyrosine dephosphorylation [GO:0035335],
regulation of protein import into nucleus [GO:0042306],
regulation of phosphorylation [GO:0042325],
proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161],
cellular macromolecule metabolic process [GO:0044260],
negative regulation of cell cycle [GO:0045786],
regulation of protein kinase activity [GO:0045859],
carbohydrate phosphorylation [GO:0046835],
phosphorylated carbohydrate dephosphorylation [GO:0046838],
habituation [GO:0046959],
regulation of proteasomal protein catabolic process [GO:0061136],
regulation of protein localization to plasma membrane [GO:1903076],
regulation of ubiquitin protein ligase activity [GO:1904666],
regulation of glycogen (starch) synthase activity [GO:2000465],

Molecular Function:
protein binding [GO:0005515],
glycogen (starch) synthase activity [GO:0004373],
phosphoprotein phosphatase activity [GO:0004721],
protein serine/threonine phosphatase activity [GO:0004722],
protein tyrosine phosphatase activity [GO:0004725],
protein tyrosine/serine/threonine phosphatase activity [GO:0008138],
hydrolase activity [GO:0016787],
phosphatase activity [GO:0016791],
carbohydrate phosphatase activity [GO:0019203],
carbohydrate binding [GO:0030246],
polysaccharide binding [GO:0030247],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
protein dimerization activity [GO:0046983],
starch binding [GO:2001070],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
endoplasmic reticulum [GO:0005783],
cytosol [GO:0005829],
polysome [GO:0005844],
plasma membrane [GO:0005886],
membrane [GO:0016020],
dendrite [GO:0030425],
perikaryon [GO:0043204],
cytoplasmic side of endoplasmic reticulum membrane [GO:0098554],
cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556],