EP300

E1A binding protein p300

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
20084294 Primary keratinocytes derived from skin Human NO
25867071 NCI-H1299 Human NO
30307152 Primary mesenchymal cells derived from blood, primary osteogenic cells derived from bone Human, mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
12414652 Neonatal Human melanocytes Human NO
21915115 TIG-3, BJ, Saos-2, HDF1 Human NO
28425985 Reh, rimary cells derived from bone marrow, primary cells derived from blood Human NO
30266801 WM26644, SK-MEL-5 Human NO
31122700 Primary mesenchymal stromal cells derived from umbilical cord Human NO
32029712 Primary synovial fibroblast Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
response to hypoxia [GO:0001666],
somitogenesis [GO:0001756],
thigmotaxis [GO:0001966],
behavioral defense response [GO:0002209],
stimulatory C-type lectin receptor signaling pathway [GO:0002223],
regulation of glycolytic process [GO:0006110],
transcription-coupled nucleotide-excision repair [GO:0006283],
regulation of transcription, DNA-templated [GO:0006355],
protein acetylation [GO:0006473],
internal protein amino acid acetylation [GO:0006475],
apoptotic process [GO:0006915],
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977],
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [GO:0006990],
Notch signaling pathway [GO:0007219],
positive regulation of transcription of Notch receptor target [GO:0007221],
nervous system development [GO:0007399],
heart development [GO:0007507],
skeletal muscle tissue development [GO:0007519],
learning or memory [GO:0007611],
circadian rhythm [GO:0007623],
animal organ morphogenesis [GO:0009887],
regulation of autophagy [GO:0010506],
macrophage derived foam cell differentiation [GO:0010742],
regulation of mitochondrion organization [GO:0010821],
positive regulation of neuron projection development [GO:0010976],
viral process [GO:0016032],
histone acetylation [GO:0016573],
protein deubiquitination [GO:0016579],
N-terminal peptidyl-lysine acetylation [GO:0018076],
internal peptidyl-lysine acetylation [GO:0018393],
peptidyl-lysine acetylation [GO:0018394],
B cell differentiation [GO:0030183],
platelet formation [GO:0030220],
lung development [GO:0030324],
positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511],
negative regulation of protein complex assembly [GO:0031333],
protein destabilization [GO:0031648],
positive regulation of protein binding [GO:0032092],
positive regulation of type I interferon production [GO:0032481],
cellular response to UV [GO:0034644],
multicellular organism growth [GO:0035264],
megakaryocyte development [GO:0035855],
swimming [GO:0036268],
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771],
response to estrogen [GO:0043627],
positive regulation by host of viral transcription [GO:0043923],
histone H4 acetylation [GO:0043967],
histone H2B acetylation [GO:0043969],
fat cell differentiation [GO:0045444],
regulation of megakaryocyte differentiation [GO:0045652],
negative regulation of gluconeogenesis [GO:0045721],
positive regulation of Notch signaling pathway [GO:0045747],
positive regulation of gene expression, epigenetic [GO:0045815],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
protein stabilization [GO:0050821],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
regulation of cell cycle [GO:0051726],
face morphogenesis [GO:0060325],
regulation of androgen receptor signaling pathway [GO:0060765],
regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418],
regulation of tubulin deacetylation [GO:0090043],
regulation of cellular response to heat [GO:1900034],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
regulation of signal transduction by p53 class mediator [GO:1901796],
beta-catenin-TCF complex assembly [GO:1904837],
positive regulation of protein phosphorylation [GO:0001934],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
cell cycle [GO:0007049],
response to glucose [GO:0009749],
positive regulation of glycoprotein biosynthetic process [GO:0010560],
positive regulation of gene expression [GO:0010628],
positive regulation of cell death [GO:0010942],
positive regulation of muscle atrophy [GO:0014737],
cell differentiation [GO:0030154],
positive regulation of cell growth [GO:0030307],
negative regulation of cellular metabolic process [GO:0031324],
positive regulation of cellular metabolic process [GO:0031325],
positive regulation of collagen biosynthetic process [GO:0032967],
positive regulation of histone acetylation [GO:0035066],
positive regulation of protein import into nucleus [GO:0042307],
response to drug [GO:0042493],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
positive regulation of DNA binding [GO:0043388],
protein kinase B signaling [GO:0043491],
histone H3 acetylation [GO:0043966],
positive regulation of translation [GO:0045727],
positive regulation of axon extension [GO:0045773],
positive regulation of cell size [GO:0045793],
positive regulation of proteolysis [GO:0045862],
rhythmic process [GO:0048511],
positive regulation of protein secretion [GO:0050714],
cartilage development [GO:0051216],
response to calcium ion [GO:0051592],
regulation of angiotensin metabolic process [GO:0060177],
positive regulation of sarcomere organization [GO:0060298],
negative regulation of cell death [GO:0060548],
positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051],
protein-DNA complex assembly [GO:0065004],
response to dexamethasone [GO:0071548],
positive regulation of protein acetylation [GO:1901985],
negative regulation of miRNA metabolic process [GO:2000629],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor binding [GO:0001085],
RNA polymerase II activating transcription factor binding [GO:0001102],
p53 binding [GO:0002039],
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
damaged DNA binding [GO:0003684],
transcription coactivator activity [GO:0003713],
histone acetyltransferase activity [GO:0004402],
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [GO:0004468],
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
protein C-terminus binding [GO:0008022],
transcription factor binding [GO:0008134],
zinc ion binding [GO:0008270],
acetyltransferase activity [GO:0016407],
transferase activity, transferring acyl groups [GO:0016746],
chromatin DNA binding [GO:0031490],
activating transcription factor binding [GO:0033613],
nuclear hormone receptor binding [GO:0035257],
tau protein binding [GO:0048156],
androgen receptor binding [GO:0050681],
NF-kappaB binding [GO:0051059],
peptide-lysine-N-acetyltransferase activity [GO:0061733],
pre-mRNA intronic binding [GO:0097157],
STAT family protein binding [GO:0097677],
core promoter proximal region sequence-specific DNA binding [GO:0000987],
transcription cofactor activity [GO:0003712],
antigen binding [GO:0003823],
transferase activity [GO:0016740],
protein kinase binding [GO:0019901],
glucocorticoid receptor binding [GO:0035259],
peroxisome proliferator activated receptor binding [GO:0042975],
bHLH transcription factor binding [GO:0043425],
macromolecular complex binding [GO:0044877],
SMAD binding [GO:0046332],
metal ion binding [GO:0046872],
mitogen-activated protein kinase binding [GO:0051019],
protein antigen binding [GO:1990405],
promoter-specific chromatin binding [GO:1990841],

Cellular Component:
histone acetyltransferase complex [GO:0000123],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
chromosome [GO:0005694],
cytosol [GO:0005829],
protein-DNA complex [GO:0032993],
host cell nucleus [GO:0042025],
chromatin [GO:0000785],
cytoplasm [GO:0005737],
macromolecular complex [GO:0032991],