enolase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
26734996 PT45, MDA-MB-231, NCI-H441 Human NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
gluconeogenesis [GO:0006094],
glycolytic process [GO:0006096],
response to virus [GO:0009615],
positive regulation of plasminogen activation [GO:0010756],
negative regulation of cell growth [GO:0030308],
regulation of vacuole fusion, non-autophagic [GO:0032889],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of muscle contraction [GO:0045933],
canonical glycolysis [GO:0061621],
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298],
positive regulation of ATP biosynthetic process [GO:2001171],
in utero embryonic development [GO:0001701],
positive regulation of binding [GO:0051099],
cellular response to acid chemical [GO:0071229],
cellular response to interleukin-7 [GO:0098761],

Molecular Function:
magnesium ion binding [GO:0000287],
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
RNA binding [GO:0003723],
phosphopyruvate hydratase activity [GO:0004634],
protein binding [GO:0005515],
protein homodimerization activity [GO:0042803],
cadherin binding [GO:0045296],
GTPase binding [GO:0051020],
enzyme binding [GO:0019899],
heat shock protein binding [GO:0031072],
identical protein binding [GO:0042802],
macromolecular complex binding [GO:0044877],

Cellular Component:
phosphopyruvate hydratase complex [GO:0000015],
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
membrane [GO:0016020],
M band [GO:0031430],
extracellular exosome [GO:0070062],
cell cortex region [GO:0099738],
extrinsic component of plasma membrane [GO:0019897],
growth cone [GO:0030426],
neuron projection [GO:0043005],
myelin sheath [GO:0043209],
membrane raft [GO:0045121],
synaptic membrane [GO:0097060],