ENG

endoglin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
18974388 HUVEC Human NO
27067789 Primary epithelial cells derived from peritoneum Human NO
31155496 Primary β cells derived from pancreas Mouse YES
31219154 MCF10A Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
30854802 Primary progenitor cells derived from heart Human NO
31983656 MSC Human YES

GO terms:

Biological Process:
chronological cell aging [GO:0001300],
angiogenesis [GO:0001525],
patterning of blood vessels [GO:0001569],
vasculogenesis [GO:0001570],
epithelial to mesenchymal transition [GO:0001837],
positive regulation of protein phosphorylation [GO:0001934],
heart looping [GO:0001947],
sprouting angiogenesis [GO:0002040],
outflow tract septum morphogenesis [GO:0003148],
epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198],
endocardial cushion morphogenesis [GO:0003203],
cardiac ventricle morphogenesis [GO:0003208],
cardiac atrium morphogenesis [GO:0003209],
ventricular trabecula myocardium morphogenesis [GO:0003222],
cell migration involved in endocardial cushion formation [GO:0003273],
regulation of transcription, DNA-templated [GO:0006355],
cell adhesion [GO:0007155],
transforming growth factor beta receptor signaling pathway [GO:0007179],
negative regulation of gene expression [GO:0010629],
regulation of cardiac muscle cell apoptotic process [GO:0010665],
positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862],
cell migration [GO:0016477],
regulation of transforming growth factor beta receptor signaling pathway [GO:0017015],
central nervous system vasculogenesis [GO:0022009],
negative regulation of cell migration [GO:0030336],
BMP signaling pathway [GO:0030509],
positive regulation of BMP signaling pathway [GO:0030513],
negative regulation of protein autophosphorylation [GO:0031953],
response to corticosteroid [GO:0031960],
positive regulation of collagen biosynthetic process [GO:0032967],
dorsal aorta morphogenesis [GO:0035912],
response to drug [GO:0042493],
positive regulation of angiogenesis [GO:0045766],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
smooth muscle tissue development [GO:0048745],
artery morphogenesis [GO:0048844],
venous blood vessel morphogenesis [GO:0048845],
positive regulation of protein kinase B signaling [GO:0051897],
atrial cardiac muscle tissue morphogenesis [GO:0055009],
bone development [GO:0060348],
extracellular matrix constituent secretion [GO:0070278],
cellular response to mechanical stimulus [GO:0071260],
endocardial cushion to mesenchymal transition [GO:0090500],
vascular smooth muscle cell development [GO:0097084],
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007],
positive regulation of vascular smooth muscle cell differentiation [GO:1905065],
atrioventricular canal morphogenesis [GO:1905222],
regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:1905310],
regulation of cell proliferation involved in heart morphogenesis [GO:2000136],
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
response to hypoxia [GO:0001666],
negative regulation of endothelial cell proliferation [GO:0001937],
positive regulation of systemic arterial blood pressure [GO:0003084],
heart development [GO:0007507],
positive regulation of gene expression [GO:0010628],
extracellular matrix disassembly [GO:0022617],
wound healing [GO:0042060],
cell motility [GO:0048870],
negative regulation of nitric-oxide synthase activity [GO:0051001],
cell chemotaxis [GO:0060326],
negative regulation of pathway-restricted SMAD protein phosphorylation [GO:0060394],
detection of hypoxia [GO:0070483],
cardiac jelly development [GO:1905072],

Molecular Function:
transmembrane signaling receptor activity [GO:0004888],
transforming growth factor beta-activated receptor activity [GO:0005024],
type II transforming growth factor beta receptor binding [GO:0005114],
protein binding [GO:0005515],
galactose binding [GO:0005534],
glycosaminoglycan binding [GO:0005539],
coreceptor activity [GO:0015026],
type I transforming growth factor beta receptor binding [GO:0034713],
BMP binding [GO:0036122],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
activin binding [GO:0048185],
transforming growth factor beta binding [GO:0050431],

Cellular Component:
extracellular space [GO:0005615],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
external side of plasma membrane [GO:0009897],
cell surface [GO:0009986],
integral component of membrane [GO:0016021],
nuclear body [GO:0016604],
receptor complex [GO:0043235],
endothelial microparticle [GO:0072563],
membrane [GO:0016020],