EIF4G3

eukaryotic translation initiation factor 4 gamma 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
31945054 IMR-90 Human YES

GO terms:

Biological Process:
translational initiation [GO:0006413],
regulation of translational initiation [GO:0006446],
negative regulation of autophagy [GO:0010507],
positive regulation of protein phosphorylation [GO:0001934],
translation [GO:0006412],
regulation of translation [GO:0006417],
spermatogenesis [GO:0007283],
positive regulation of translation [GO:0045727],
positive regulation of meiosis I [GO:0060903],

Molecular Function:
RNA cap binding [GO:0000339],
RNA binding [GO:0003723],
mRNA binding [GO:0003729],
translation initiation factor activity [GO:0003743],
translation factor activity, RNA binding [GO:0008135],
protein binding [GO:0005515],

Cellular Component:
cytosol [GO:0005829],
eukaryotic translation initiation factor 4F complex [GO:0016281],