EIF2AK4

eukaryotic translation initiation factor 2 alpha kinase 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28894140 HK-2 Human NO

GO terms:

Biological Process:
DNA damage checkpoint [GO:0000077],
positive regulation of defense response to virus by host [GO:0002230],
adaptive immune response [GO:0002250],
T cell activation involved in immune response [GO:0002286],
immune system process [GO:0002376],
positive regulation of adaptive immune response [GO:0002821],
regulation of translation [GO:0006417],
regulation of translational initiation [GO:0006446],
protein phosphorylation [GO:0006468],
cell cycle [GO:0007049],
cell cycle arrest [GO:0007050],
nervous system development [GO:0007399],
learning [GO:0007612],
long-term memory [GO:0007616],
cellular response to starvation [GO:0009267],
positive regulation of gene expression [GO:0010628],
regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998],
viral process [GO:0016032],
phosphorylation [GO:0016310],
negative regulation of translation [GO:0017148],
viral translation [GO:0019081],
cell differentiation [GO:0030154],
endoplasmic reticulum unfolded protein response [GO:0030968],
negative regulation of translational initiation in response to stress [GO:0032057],
negative regulation of CREB transcription factor activity [GO:0032792],
cellular response to amino acid starvation [GO:0034198],
cellular response to UV [GO:0034644],
response to endoplasmic reticulum stress [GO:0034976],
eiF2alpha phosphorylation in response to endoplasmic reticulum stress [GO:0036492],
induction by virus of host autophagy [GO:0039520],
regulation of translational initiation in response to stress [GO:0043558],
negative regulation by host of viral genome replication [GO:0044828],
negative regulation of neuron differentiation [GO:0045665],
negative regulation of translational initiation [GO:0045947],
protein autophosphorylation [GO:0046777],
defense response to virus [GO:0051607],
regulation of feeding behavior [GO:0060259],
regulation of eIF2 alpha phosphorylation by amino acid starvation [GO:0060733],
cellular response to cold [GO:0070417],
positive regulation of translational initiation in response to starvation [GO:0071264],
positive regulation of long-term synaptic potentiation [GO:1900273],
neuron projection extension [GO:1990138],
cellular response to leucine starvation [GO:1990253],

Molecular Function:
tRNA binding [GO:0000049],
nucleotide binding [GO:0000166],
RNA binding [GO:0003723],
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694],
protein binding [GO:0005515],
ATP binding [GO:0005524],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
eukaryotic initiation factor eIF2 binding [GO:0071074],

Cellular Component:
intracellular [GO:0005622],
cytoplasm [GO:0005737],
polysome [GO:0005844],
cytosolic ribosome [GO:0022626],