EIF2AK3

eukaryotic translation initiation factor 2 alpha kinase 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30213560 NHEKs Human NO
30912009 Adipose tissue Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27977682 Primary cells derived from melanoma Mouse NO

GO terms:

Biological Process:
skeletal system development [GO:0001501],
ossification [GO:0001503],
angiogenesis [GO:0001525],
chondrocyte development [GO:0002063],
protein phosphorylation [GO:0006468],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
ER overload response [GO:0006983],
endoplasmic reticulum organization [GO:0007029],
positive regulation of vascular endothelial growth factor production [GO:0010575],
positive regulation of gene expression [GO:0010628],
regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998],
negative regulation of translation [GO:0017148],
peptidyl-serine phosphorylation [GO:0018105],
calcium-mediated signaling [GO:0019722],
bone mineralization [GO:0030282],
endoplasmic reticulum unfolded protein response [GO:0030968],
endocrine pancreas development [GO:0031018],
negative regulation of myelination [GO:0031642],
negative regulation of translational initiation in response to stress [GO:0032057],
cellular response to amino acid starvation [GO:0034198],
response to endoplasmic reticulum stress [GO:0034976],
eiF2alpha phosphorylation in response to endoplasmic reticulum stress [GO:0036492],
PERK-mediated unfolded protein response [GO:0036499],
cellular response to glucose starvation [GO:0042149],
positive regulation of transcription from RNA polymerase I promoter [GO:0045943],
protein autophosphorylation [GO:0046777],
insulin-like growth factor receptor signaling pathway [GO:0048009],
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:0060734],
cellular response to cold [GO:0070417],
positive regulation of protein localization to nucleus [GO:1900182],
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902235],
response to manganese-induced endoplasmic reticulum stress [GO:1990737],
translation [GO:0006412],
regulation of translation [GO:0006417],
response to unfolded protein [GO:0006986],
lactation [GO:0007595],
positive regulation of signal transduction [GO:0009967],
negative regulation of gene expression [GO:0010629],
phosphorylation [GO:0016310],
regulation of fatty acid metabolic process [GO:0019217],
pancreas development [GO:0031016],
negative regulation of translation in response to stress [GO:0032055],
positive regulation of protein binding [GO:0032092],
SREBP signaling pathway [GO:0032933],
negative regulation of apoptotic process [GO:0043066],
fat cell differentiation [GO:0045444],
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059],
negative regulation of translation in response to endoplasmic reticulum stress [GO:1902010],
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237],
positive regulation of glutathione biosynthetic process [GO:1903788],
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694],
protein binding [GO:0005515],
ATP binding [GO:0005524],
enzyme binding [GO:0019899],
protein phosphatase binding [GO:0019903],
identical protein binding [GO:0042802],
Hsp90 protein binding [GO:0051879],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
eukaryotic initiation factor eIF2 binding [GO:0071074],

Cellular Component:
cytoplasm [GO:0005737],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
membrane [GO:0016020],
cytosolic ribosome [GO:0022626],
integral component of endoplasmic reticulum membrane [GO:0030176],
perinuclear region of cytoplasm [GO:0048471],
integral component of membrane [GO:0016021],