AKT1

AKT serine/threonine kinase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
16339764 EPCs Human NO
19293429 Aorta Mouse NO
21072054 U-87, U251, U373, LN18, LN429 Human NO
21909130 IMR-90  Human NO
23523798 HCT116 Human NO
27619662 VSMCs Muscle Human NO
27702651 A375, 293A, 293T, 293FT, B16, A259, HeLa, U-87 Human NO
28656269 MSCs rat NO
28691365 EJ, H1299, WI-38 Human NO
29224011 HMECs Endothelium Human NO
29991711 HUVEC Human NO
31124078 G08 Human NO
31617338 HCT 116, MCF-7 Human NO
31622846 BJ Human NO
32012719 Primary epithelial ovarian cancer cells Human NO
32963699 Primary cells derived from mesenchyma Human No
32963699 Primary cells derived from mesenchyma Human No
31610028 MHCC97-L, Huh-7, PLC/PRF/5 Human No
33066597 PK-1, T3M-4 Human No
33364043 heart Rat No
32952639 Primary chondrocyte derived from cartilage Rat NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
21191179 B-CPAP Human NO
21474066 IMR-90 Pancreas Human, mouse NO
21881167 MCF7 Human NO
24476133 DD-HLM, primary leiomyoma cells Human NO
25753771 Primary multipotent cells derived from skin Foreskin Human NO
25766527 Aorta Mouse NO
28915637 H929, OCI-MY5, APR1, OPM-2, MEF Human, mouse NO
30742942 MDA-MB-231, MDA-MB-468, BT-549, SK-BR-3, MCF-7, BT474 Breast Human NO
31047988 Heart Mouse NO
31089945 HGMC Human NO
31182679 HUVEC Human NO
31467258 Primary neurons derived from brain Mouse NO
31510944 U-87 Human NO
31512783 Prostate Human NO
31602539 HDF Human NO
31610028 Huh-7, PLC/PRF/5 Human NO
31639393 MKN28, MKN45 Human NO
31931659 WI-38 Human NO
31978448 A549 Human NO
32404543 HDF Human NO
32599680 SW480, HCT 116 Human No
32570219 Primary fibroblasts derived from skin Human NO
32570219 Primary fibroblasts derived from skin mouse NO
32570211 C2C12 Mouse NO

GO terms:

Biological Process:
osteoblast differentiation [GO:0001649],
maternal placenta development [GO:0001893],
positive regulation of protein phosphorylation [GO:0001934],
positive regulation of endothelial cell proliferation [GO:0001938],
cell migration involved in sprouting angiogenesis [GO:0002042],
glycogen biosynthetic process [GO:0005978],
regulation of glycogen biosynthetic process [GO:0005979],
glucose metabolic process [GO:0006006],
translation [GO:0006412],
regulation of translation [GO:0006417],
protein phosphorylation [GO:0006468],
negative regulation of protein kinase activity [GO:0006469],
protein import into nucleus [GO:0006606],
nitric oxide biosynthetic process [GO:0006809],
activation-induced cell death of T cells [GO:0006924],
inflammatory response [GO:0006954],
cellular response to DNA damage stimulus [GO:0006974],
response to oxidative stress [GO:0006979],
signal transduction [GO:0007165],
epidermal growth factor receptor signaling pathway [GO:0007173],
G-protein coupled receptor signaling pathway [GO:0007186],
I-kappaB kinase/NF-kappaB signaling [GO:0007249],
germ cell development [GO:0007281],
aging [GO:0007568],
cell proliferation [GO:0008283],
positive regulation of cell proliferation [GO:0008284],
insulin receptor signaling pathway [GO:0008286],
apoptotic mitochondrial changes [GO:0008637],
carbohydrate transport [GO:0008643],
response to heat [GO:0009408],
negative regulation of autophagy [GO:0010507],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
negative regulation of plasma membrane long-chain fatty acid transport [GO:0010748],
positive regulation of fibroblast migration [GO:0010763],
positive regulation of sodium ion transport [GO:0010765],
positive regulation of glucose metabolic process [GO:0010907],
positive regulation of mitochondrial membrane potential [GO:0010918],
negative regulation of endopeptidase activity [GO:0010951],
regulation of neuron projection development [GO:0010975],
phosphatidylinositol 3-kinase signaling [GO:0014065],
negative regulation of macroautophagy [GO:0016242],
phosphorylation [GO:0016310],
protein ubiquitination [GO:0016567],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-threonine phosphorylation [GO:0018107],
cytokine-mediated signaling pathway [GO:0019221],
spinal cord development [GO:0021510],
cell projection organization [GO:0030030],
cell differentiation [GO:0030154],
protein catabolic process [GO:0030163],
hyaluronan metabolic process [GO:0030212],
positive regulation of cell growth [GO:0030307],
regulation of cell migration [GO:0030334],
endocrine pancreas development [GO:0031018],
T cell costimulation [GO:0031295],
negative regulation of protein ubiquitination [GO:0031397],
regulation of myelination [GO:0031641],
lipopolysaccharide-mediated signaling pathway [GO:0031663],
TOR signaling [GO:0031929],
negative regulation of fatty acid beta-oxidation [GO:0031999],
positive regulation of endodeoxyribonuclease activity [GO:0032079],
negative regulation of protein binding [GO:0032091],
response to food [GO:0032094],
activation of protein kinase B activity [GO:0032148],
positive regulation of cellular protein metabolic process [GO:0032270],
peripheral nervous system myelin maintenance [GO:0032287],
positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436],
cellular response to insulin stimulus [GO:0032869],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
response to fluid shear stress [GO:0034405],
cellular response to reactive oxygen species [GO:0034614],
intracellular signal transduction [GO:0035556],
interleukin-18-mediated signaling pathway [GO:0035655],
cellular response to vascular endothelial growth factor stimulus [GO:0035924],
NIK/NF-kappaB signaling [GO:0038061],
glucose homeostasis [GO:0042593],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
anoikis [GO:0043276],
regulation of mRNA stability [GO:0043488],
protein kinase B signaling [GO:0043491],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
positive regulation of fat cell differentiation [GO:0045600],
positive regulation of glycogen biosynthetic process [GO:0045725],
positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737],
positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742],
negative regulation of Notch signaling pathway [GO:0045746],
negative regulation of cell size [GO:0045792],
negative regulation of proteolysis [GO:0045861],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of vasoconstriction [GO:0045907],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of glucose import [GO:0046326],
negative regulation of JNK cascade [GO:0046329],
positive regulation of organ growth [GO:0046622],
protein autophosphorylation [GO:0046777],
positive regulation of lipid biosynthetic process [GO:0046889],
insulin-like growth factor receptor signaling pathway [GO:0048009],
positive regulation of smooth muscle cell proliferation [GO:0048661],
regulation of nitric-oxide synthase activity [GO:0050999],
positive regulation of nitric-oxide synthase activity [GO:0051000],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
striated muscle cell differentiation [GO:0051146],
negative regulation of protein kinase B signaling [GO:0051898],
excitatory postsynaptic potential [GO:0060079],
response to growth hormone [GO:0060416],
mammary gland epithelial cell differentiation [GO:0060644],
labyrinthine layer blood vessel development [GO:0060716],
response to UV-A [GO:0070141],
cellular response to mechanical stimulus [GO:0071260],
cellular response to cadmium ion [GO:0071276],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to epidermal growth factor stimulus [GO:0071364],
cellular response to prostaglandin E stimulus [GO:0071380],
cellular response to organic cyclic compound [GO:0071407],
cellular response to hypoxia [GO:0071456],
negative regulation of protein serine/threonine kinase activity [GO:0071901],
establishment of protein localization to mitochondrion [GO:0072655],
maintenance of protein location in mitochondrion [GO:0072656],
negative regulation of release of cytochrome c from mitochondria [GO:0090201],
cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011],
execution phase of apoptosis [GO:0097194],
negative regulation of protein kinase activity by protein phosphorylation [GO:0100002],
positive regulation of G1/S transition of mitotic cell cycle [GO:1900087],
positive regulation of protein localization to nucleus [GO:1900182],
negative regulation of neuron death [GO:1901215],
regulation of signal transduction by p53 class mediator [GO:1901796],
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176],
negative regulation of leukocyte cell-cell adhesion [GO:1903038],
positive regulation of protein localization to plasma membrane [GO:1903078],
positive regulation of I-kappaB phosphorylation [GO:1903721],
cellular response to nerve growth factor stimulus [GO:1990090],
response to insulin-like growth factor stimulus [GO:1990418],
positive regulation of protein localization to cell surface [GO:2000010],
negative regulation of lymphocyte migration [GO:2000402],
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240],
carbohydrate metabolic process [GO:0005975],
glycogen metabolic process [GO:0005977],
apoptotic process [GO:0006915],
cytoskeleton organization [GO:0007010],
multicellular organism development [GO:0007275],
nervous system development [GO:0007399],
response to hormone [GO:0009725],
response to organic substance [GO:0010033],
gene expression [GO:0010467],
regulation of protein localization [GO:0032880],
cellular response to decreased oxygen levels [GO:0036294],
anagen [GO:0042640],
glycogen cell differentiation involved in embryonic placenta development [GO:0060709],
cellular response to growth factor stimulus [GO:0071363],
cellular response to peptide [GO:1901653],
negative regulation of intrinsic apoptotic signaling pathway [GO:2001243],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
protein serine/threonine/tyrosine kinase activity [GO:0004712],
protein kinase C binding [GO:0005080],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
ATP binding [GO:0005524],
phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547],
kinase activity [GO:0016301],
enzyme binding [GO:0019899],
nitric-oxide synthase regulator activity [GO:0030235],
GTPase activating protein binding [GO:0032794],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
phosphatidylinositol-3,4-bisphosphate binding [GO:0043325],
protein phosphatase 2A binding [GO:0051721],
14-3-3 protein binding [GO:0071889],
nucleotide binding [GO:0000166],
transferase activity [GO:0016740],
protein kinase binding [GO:0019901],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
spindle [GO:0005819],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell-cell junction [GO:0005911],
microtubule cytoskeleton [GO:0015630],
vesicle [GO:0031982],
macromolecular complex [GO:0032991],
ciliary basal body [GO:0036064],
postsynapse [GO:0098794],
membrane [GO:0016020],