EGFR

epidermal growth factor receptor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
14499637 Hs68 Human NO
23746120 2BS Human NO
26360782 Primary progenitor cells derived from blood Human NO
28459363 GBC-SD, NOZ Gallblader Human NO
29548335 Li Fraumeni Human YES
30514230 U-251 MG Human NO
30910997 U2OS, U-87 MG, A-172, A278, MCF7, HT-18, LoVo, A549, HCT 116 Human NO
31935369 PC-9, HCC827 Human NO
31945125 Primary astrocytes derived from brain Human YES
32599680 HCT 116 Human No
32599680 SW480 Human No

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
activation of MAPKK activity [GO:0000186],
ossification [GO:0001503],
embryonic placenta development [GO:0001892],
positive regulation of protein phosphorylation [GO:0001934],
hair follicle development [GO:0001942],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
translation [GO:0006412],
response to osmotic stress [GO:0006970],
signal transduction [GO:0007165],
cell surface receptor signaling pathway [GO:0007166],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
epidermal growth factor receptor signaling pathway [GO:0007173],
activation of phospholipase C activity [GO:0007202],
multicellular organism development [GO:0007275],
salivary gland morphogenesis [GO:0007435],
midgut development [GO:0007494],
learning or memory [GO:0007611],
circadian rhythm [GO:0007623],
positive regulation of cell proliferation [GO:0008284],
positive regulation of nitric oxide mediated signal transduction [GO:0010750],
magnesium ion homeostasis [GO:0010960],
regulation of phosphatidylinositol 3-kinase signaling [GO:0014066],
diterpenoid metabolic process [GO:0016101],
peptidyl-tyrosine phosphorylation [GO:0018108],
cerebral cortex cell migration [GO:0021795],
cell differentiation [GO:0030154],
positive regulation of cell growth [GO:0030307],
lung development [GO:0030324],
positive regulation of cell migration [GO:0030335],
positive regulation of superoxide anion generation [GO:0032930],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
response to cobalamin [GO:0033590],
response to hydroxyisoflavone [GO:0033594],
positive regulation of kinase activity [GO:0033674],
cellular response to reactive oxygen species [GO:0034614],
peptidyl-tyrosine autophosphorylation [GO:0038083],
ERBB2 signaling pathway [GO:0038128],
negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059],
wound healing [GO:0042060],
negative regulation of protein catabolic process [GO:0042177],
positive regulation of phosphorylation [GO:0042327],
ovulation cycle [GO:0042698],
hydrogen peroxide metabolic process [GO:0042743],
activation of phospholipase A2 activity by calcium-mediated signaling [GO:0043006],
negative regulation of apoptotic process [GO:0043066],
positive regulation of MAP kinase activity [GO:0043406],
tongue development [GO:0043586],
positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737],
positive regulation of DNA repair [GO:0045739],
positive regulation of DNA replication [GO:0045740],
negative regulation of Notch signaling pathway [GO:0045746],
positive regulation of bone resorption [GO:0045780],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of vasoconstriction [GO:0045907],
negative regulation of mitotic cell cycle [GO:0045930],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
regulation of JNK cascade [GO:0046328],
viral entry into host cell [GO:0046718],
protein autophosphorylation [GO:0046777],
astrocyte activation [GO:0048143],
positive regulation of fibroblast proliferation [GO:0048146],
digestive tract morphogenesis [GO:0048546],
positive regulation of smooth muscle cell proliferation [GO:0048661],
neuron projection morphogenesis [GO:0048812],
positive regulation of epithelial cell proliferation [GO:0050679],
positive regulation of inflammatory response [GO:0050729],
regulation of peptidyl-tyrosine phosphorylation [GO:0050730],
regulation of nitric-oxide synthase activity [GO:0050999],
protein insertion into membrane [GO:0051205],
response to calcium ion [GO:0051592],
positive regulation of protein kinase B signaling [GO:0051897],
positive regulation of synaptic transmission, glutamatergic [GO:0051968],
morphogenesis of an epithelial fold [GO:0060571],
membrane organization [GO:0061024],
eyelid development in camera-type eye [GO:0061029],
response to UV-A [GO:0070141],
regulation of ERK1 and ERK2 cascade [GO:0070372],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to amino acid stimulus [GO:0071230],
cellular response to mechanical stimulus [GO:0071260],
cellular response to cadmium ion [GO:0071276],
cellular response to epidermal growth factor stimulus [GO:0071364],
cellular response to estradiol stimulus [GO:0071392],
cellular response to dexamethasone stimulus [GO:0071549],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
liver regeneration [GO:0097421],
cell-cell adhesion [GO:0098609],
positive regulation of protein kinase C activity [GO:1900020],
positive regulation of G1/S transition of mitotic cell cycle [GO:1900087],
negative regulation of ERBB signaling pathway [GO:1901185],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
positive regulation of prolactin secretion [GO:1902722],
positive regulation of protein localization to plasma membrane [GO:1903078],
positive regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903800],
negative regulation of cardiocyte differentiation [GO:1905208],
regulation of cell motility [GO:2000145],
cell morphogenesis [GO:0000902],
protein phosphorylation [GO:0006468],
epidermis development [GO:0008544],
phosphorylation [GO:0016310],
intracellular signal transduction [GO:0035556],
regulation of cell proliferation [GO:0042127],
cellular response to growth factor stimulus [GO:0071363],

Molecular Function:
virus receptor activity [GO:0001618],
chromatin binding [GO:0003682],
double-stranded DNA binding [GO:0003690],
MAP kinase kinase kinase activity [GO:0004709],
protein tyrosine kinase activity [GO:0004713],
transmembrane receptor protein tyrosine kinase activity [GO:0004714],
transmembrane signaling receptor activity [GO:0004888],
epidermal growth factor-activated receptor activity [GO:0005006],
integrin binding [GO:0005178],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
ATP binding [GO:0005524],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
protein phosphatase binding [GO:0019903],
nitric-oxide synthase regulator activity [GO:0030235],
ubiquitin protein ligase binding [GO:0031625],
identical protein binding [GO:0042802],
cadherin binding [GO:0045296],
epidermal growth factor binding [GO:0048408],
actin filament binding [GO:0051015],
ATPase binding [GO:0051117],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
receptor binding [GO:0005102],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
macromolecular complex binding [GO:0044877],

Cellular Component:
Golgi membrane [GO:0000139],
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
endosome [GO:0005768],
endoplasmic reticulum membrane [GO:0005789],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
focal adhesion [GO:0005925],
basal plasma membrane [GO:0009925],
cell surface [GO:0009986],
endosome membrane [GO:0010008],
membrane [GO:0016020],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
cell junction [GO:0030054],
endocytic vesicle [GO:0030139],
clathrin-coated vesicle membrane [GO:0030665],
early endosome membrane [GO:0031901],
nuclear membrane [GO:0031965],
macromolecular complex [GO:0032991],
receptor complex [GO:0043235],
membrane raft [GO:0045121],
synapse [GO:0045202],
perinuclear region of cytoplasm [GO:0048471],
Shc-EGFR complex [GO:0070435],
multivesicular body, internal vesicle lumen [GO:0097489],
intracellular [GO:0005622],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
integral component of membrane [GO:0016021],