EEF1A1

eukaryotic translation elongation factor 1 alpha 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
19487283 MCF7, MDA-MB 231, NCI-H46, HCT 116, primary fibroblasts derived from skin, primary fibroblasts derived from embryonic tissue Human NO
31945054 IMR-90 Human YES

GO terms:

Biological Process:
translation [GO:0006412],
translational elongation [GO:0006414],
neutrophil degranulation [GO:0043312],
cellular response to epidermal growth factor stimulus [GO:0071364],
regulation of D-erythro-sphingosine kinase activity [GO:1900022],
regulation of chaperone-mediated autophagy [GO:1904714],
positive regulation of cell death [GO:0010942],
positive regulation of neuron projection development [GO:0010976],
negative regulation of reactive oxygen species biosynthetic process [GO:1903427],

Molecular Function:
tRNA binding [GO:0000049],
RNA binding [GO:0003723],
translation elongation factor activity [GO:0003746],
GTPase activity [GO:0003924],
protein binding [GO:0005515],
GTP binding [GO:0005525],
kinase binding [GO:0019900],
protein kinase binding [GO:0019901],
nucleotide binding [GO:0000166],
mRNA binding [GO:0003729],
calmodulin binding [GO:0005516],
drug binding [GO:0008144],
identical protein binding [GO:0042802],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
eukaryotic translation elongation factor 1 complex [GO:0005853],
plasma membrane [GO:0005886],
membrane [GO:0016020],
cortical actin cytoskeleton [GO:0030864],
ruffle membrane [GO:0032587],
secretory granule lumen [GO:0034774],
extracellular exosome [GO:0070062],
cytoplasmic side of lysosomal membrane [GO:0098574],
ficolin-1-rich granule lumen [GO:1904813],
myelin sheath [GO:0043209],