AKR1C2
aldo-keto reductase family 1 member C2
Link to human orthologSearch for interactions with genes linked to senescence.
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 24929818 | Primary keratinocytes derived from skin | Human | NO | |
| 29321003 | Primary bronchial epithelial cells derived from lung | Human | YES | |
| 29548335 | Li Fraumeni | Human | YES | |
| 30626320 | Primary bronchial epithelial cells derived from lung | Human | NO | |
| 31945054 | IMR-90 | Human | YES | |
GO terms:
Biological Process:
prostaglandin metabolic process [GO:0006693],
G-protein coupled receptor signaling pathway [GO:0007186],
digestion [GO:0007586],
steroid metabolic process [GO:0008202],
C21-steroid hormone metabolic process [GO:0008207],
positive regulation of cell proliferation [GO:0008284],
epithelial cell differentiation [GO:0030855],
progesterone metabolic process [GO:0042448],
daunorubicin metabolic process [GO:0044597],
doxorubicin metabolic process [GO:0044598],
positive regulation of protein kinase B signaling [GO:0051897],
oxidation-reduction process [GO:0055114],
cellular response to jasmonic acid stimulus [GO:0071395],
cellular response to prostaglandin D stimulus [GO:0071799],
Molecular Function:
alditol:NADP+ 1-oxidoreductase activity [GO:0004032],
steroid binding [GO:0005496],
alcohol dehydrogenase (NADP+) activity [GO:0008106],
steroid dehydrogenase activity [GO:0016229],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655],
phenanthrene 9,10-monooxygenase activity [GO:0018636],
carboxylic acid binding [GO:0031406],
bile acid binding [GO:0032052],
androsterone dehydrogenase activity [GO:0047023],
ketosteroid monooxygenase activity [GO:0047086],
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [GO:0047115],
Cellular Component:
cytosol [GO:0005829],