epithelial cell transforming 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
mitotic cytokinesis [GO:0000281],
cell morphogenesis [GO:0000902],
G-protein coupled receptor signaling pathway [GO:0007186],
nervous system development [GO:0007399],
protein transport [GO:0015031],
activation of protein kinase activity [GO:0032147],
positive regulation of cytokinesis [GO:0032467],
intracellular signal transduction [GO:0035556],
positive regulation of protein import into nucleus [GO:0042307],
positive regulation of apoptotic process [GO:0043065],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of GTPase activity [GO:0043547],
positive regulation of neuron differentiation [GO:0045666],
regulation of protein kinase activity [GO:0045859],
regulation of small GTPase mediated signal transduction [GO:0051056],
protein homooligomerization [GO:0051260],
regulation of attachment of spindle microtubules to kinetochore [GO:0051988],
cellular response to hydrogen peroxide [GO:0070301],
bicellular tight junction assembly [GO:0070830],
cellular response to calcium ion [GO:0071277],
cellular response to ionizing radiation [GO:0071479],
activation of GTPase activity [GO:0090630],
regulation of cytokinesis, actomyosin contractile ring assembly [GO:2000431],
cell cycle [GO:0007049],
cell differentiation [GO:0030154],
regulation of Rho protein signal transduction [GO:0035023],
cell division [GO:0051301],

Molecular Function:
Rho guanyl-nucleotide exchange factor activity [GO:0005089],
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
Rac guanyl-nucleotide exchange factor activity [GO:0030676],
protein homodimerization activity [GO:0042803],
guanyl-nucleotide exchange factor activity [GO:0005085],
Rho GTPase binding [GO:0017048],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
cell-cell junction [GO:0005911],
bicellular tight junction [GO:0005923],
cell cortex [GO:0005938],
nuclear body [GO:0016604],
midbody [GO:0030496],
cleavage furrow [GO:0032154],
mitotic spindle [GO:0072686],
centralspindlin complex [GO:0097149],
cytoskeleton [GO:0005856],
cell junction [GO:0030054],