AKR1C1

aldo-keto reductase family 1 member C1

Link to human ortholog


Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31945054 IMR-90 Human YES

GO terms:

Biological Process:
retinoid metabolic process [GO:0001523],
prostaglandin metabolic process [GO:0006693],
xenobiotic metabolic process [GO:0006805],
digestion [GO:0007586],
steroid metabolic process [GO:0008202],
bile acid metabolic process [GO:0008206],
C21-steroid hormone metabolic process [GO:0008207],
bile acid and bile salt transport [GO:0015721],
intestinal cholesterol absorption [GO:0030299],
epithelial cell differentiation [GO:0030855],
progesterone metabolic process [GO:0042448],
retinal metabolic process [GO:0042574],
cholesterol homeostasis [GO:0042632],
daunorubicin metabolic process [GO:0044597],
doxorubicin metabolic process [GO:0044598],
response to organophosphorus [GO:0046683],
oxidation-reduction process [GO:0055114],
cellular response to jasmonic acid stimulus [GO:0071395],

Molecular Function:
alditol:NADP+ 1-oxidoreductase activity [GO:0004032],
aldo-keto reductase (NADP) activity [GO:0004033],
steroid binding [GO:0005496],
protein binding [GO:0005515],
alcohol dehydrogenase (NADP+) activity [GO:0008106],
steroid dehydrogenase activity [GO:0016229],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [GO:0016655],
phenanthrene 9,10-monooxygenase activity [GO:0018636],
carboxylic acid binding [GO:0031406],
bile acid binding [GO:0032052],
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity [GO:0047006],
androsterone dehydrogenase activity [GO:0047023],
androsterone dehydrogenase (B-specific) activity [GO:0047042],
ketosteroid monooxygenase activity [GO:0047086],
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [GO:0047115],
indanol dehydrogenase activity [GO:0047718],

Cellular Component:
cytosol [GO:0005829],
extracellular exosome [GO:0070062],