ECE1

endothelin converting enzyme 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

GO terms:

Biological Process:
positive regulation of receptor recycling [GO:0001921],
regulation of systemic arterial blood pressure by endothelin [GO:0003100],
heart development [GO:0007507],
substance P catabolic process [GO:0010814],
bradykinin catabolic process [GO:0010815],
calcitonin catabolic process [GO:0010816],
protein processing [GO:0016485],
peptide hormone processing [GO:0016486],
regulation of vasoconstriction [GO:0019229],
endothelin maturation [GO:0034959],
hormone catabolic process [GO:0042447],
embryonic digit morphogenesis [GO:0042733],
ear development [GO:0043583],
pharyngeal system development [GO:0060037],
response to hypoxia [GO:0001666],
proteolysis [GO:0006508],
apoptotic process [GO:0006915],
regulation of blood pressure [GO:0008217],
positive regulation of cardiac muscle hypertrophy [GO:0010613],
positive regulation of cAMP-mediated signaling [GO:0043950],
positive regulation of G-protein coupled receptor protein signaling pathway [GO:0045745],
regulation of ERK1 and ERK2 cascade [GO:0070372],

Molecular Function:
endopeptidase activity [GO:0004175],
metalloendopeptidase activity [GO:0004222],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
peptide hormone binding [GO:0017046],
protein homodimerization activity [GO:0042803],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
identical protein binding [GO:0042802],
metal ion binding [GO:0046872],

Cellular Component:
lysosomal membrane [GO:0005765],
endosome [GO:0005768],
plasma membrane [GO:0005886],
external side of plasma membrane [GO:0009897],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
intrinsic component of endosome membrane [GO:0031302],
vesicle [GO:0031982],
Weibel-Palade body [GO:0033093],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
early endosome [GO:0005769],
Golgi apparatus [GO:0005794],
cell surface [GO:0009986],
secretory granule [GO:0030141],
cytoplasmic vesicle [GO:0031410],