Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
30977188 MSC Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
angiogenesis [GO:0001525],
plasma membrane repair [GO:0001778],
positive regulation of endothelial cell proliferation [GO:0001938],
monocyte activation involved in immune response [GO:0002280],
macrophage activation involved in immune response [GO:0002281],
glycerol metabolic process [GO:0006071],
vesicle fusion [GO:0006906],
muscle contraction [GO:0006936],
plasma membrane organization [GO:0007009],
negative regulation of gene expression [GO:0010629],
lipid storage [GO:0019915],
T-tubule organization [GO:0033292],
negative regulation of protein catabolic process [GO:0042177],
skeletal muscle tissue regeneration [GO:0043403],
fat cell differentiation [GO:0045444],
positive regulation of cell adhesion [GO:0045785],
muscle fiber development [GO:0048747],
cytokine secretion [GO:0050663],
negative regulation of phagocytosis [GO:0050765],
membrane fusion [GO:0061025],
cellular response to osmotic stress [GO:0071470],
positive regulation of neutrophil chemotaxis [GO:0090023],
regulation of calcium ion import [GO:0090279],
negative regulation of high voltage-gated calcium channel activity [GO:1901842],
negative regulation of protein polyubiquitination [GO:1902915],
negative regulation of microtubule depolymerization [GO:0007026],
skeletal muscle tissue development [GO:0007519],
myotube differentiation [GO:0014902],
negative regulation of protein binding [GO:0032091],
negative regulation of tubulin deacetylation [GO:1904428],

Molecular Function:
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
phospholipid binding [GO:0005543],
calcium-dependent phospholipid binding [GO:0005544],
microtubule binding [GO:0008017],
alpha-tubulin binding [GO:0043014],
lipid binding [GO:0008289],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
endosome [GO:0005768],
early endosome [GO:0005769],
late endosome [GO:0005770],
Golgi apparatus [GO:0005794],
microtubule [GO:0005874],
plasma membrane [GO:0005886],
integral component of membrane [GO:0016021],
lamellipodium [GO:0030027],
endocytic vesicle [GO:0030139],
T-tubule [GO:0030315],
cytoplasmic vesicle membrane [GO:0030659],
cytoplasmic vesicle [GO:0031410],
centriolar satellite [GO:0034451],
sarcolemma [GO:0042383],
extracellular exosome [GO:0070062],
membrane microdomain [GO:0098857],
cytoplasm [GO:0005737],
membrane [GO:0016020],