DYRK1A

dual specificity tyrosine phosphorylation regulated kinase 1A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30910997 U2OS, U-87 MG, A172, A278, MCF7, HT-18, LoVo, A549, HCT T116 Human NO

GO terms:

Biological Process:
regulation of alternative mRNA splicing, via spliceosome [GO:0000381],
protein phosphorylation [GO:0006468],
nervous system development [GO:0007399],
circadian rhythm [GO:0007623],
viral process [GO:0016032],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-threonine phosphorylation [GO:0018107],
peptidyl-tyrosine phosphorylation [GO:0018108],
negative regulation of microtubule polymerization [GO:0031115],
positive regulation of RNA splicing [GO:0033120],
beta-amyloid formation [GO:0034205],
peptidyl-serine autophosphorylation [GO:0036289],
peptidyl-tyrosine autophosphorylation [GO:0038083],
negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518],
positive regulation of transcription, DNA-templated [GO:0045893],
protein autophosphorylation [GO:0046777],
negative regulation of mRNA splicing, via spliceosome [GO:0048025],
positive regulation of protein deacetylation [GO:0090312],
phosphorylation [GO:0016310],

Molecular Function:
transcription coactivator activity [GO:0003713],
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
protein serine/threonine/tyrosine kinase activity [GO:0004712],
protein tyrosine kinase activity [GO:0004713],
non-membrane spanning protein tyrosine kinase activity [GO:0004715],
protein binding [GO:0005515],
ATP binding [GO:0005524],
identical protein binding [GO:0042802],
protein self-association [GO:0043621],
tau protein binding [GO:0048156],
tau-protein kinase activity [GO:0050321],
nucleotide binding [GO:0000166],
actin binding [GO:0003779],
cytoskeletal protein binding [GO:0008092],
tubulin binding [GO:0015631],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],
nuclear speck [GO:0016607],
axon [GO:0030424],
dendrite [GO:0030425],
ribonucleoprotein complex [GO:1990904],
microtubule [GO:0005874],
neurofilament [GO:0005883],
actin filament [GO:0005884],