DVL2

dishevelled segment polarity protein 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
neural tube closure [GO:0001843],
positive regulation of protein phosphorylation [GO:0001934],
outflow tract morphogenesis [GO:0003151],
transcription from RNA polymerase II promoter [GO:0006366],
segment specification [GO:0007379],
heart development [GO:0007507],
convergent extension involved in neural plate elongation [GO:0022007],
cellular protein localization [GO:0034613],
hippo signaling [GO:0035329],
non-canonical Wnt signaling pathway [GO:0035567],
positive regulation of JUN kinase activity [GO:0043507],
positive regulation of GTPase activity [GO:0043547],
canonical Wnt signaling pathway involved in regulation of cell proliferation [GO:0044340],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
canonical Wnt signaling pathway [GO:0060070],
Wnt signaling pathway, planar cell polarity pathway [GO:0060071],
membrane organization [GO:0061024],
positive regulation of protein tyrosine kinase activity [GO:0061098],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
cochlea morphogenesis [GO:0090103],
planar cell polarity pathway involved in neural tube closure [GO:0090179],
beta-catenin destruction complex disassembly [GO:1904886],
heart morphogenesis [GO:0003007],
multicellular organism development [GO:0007275],
Wnt signaling pathway [GO:0016055],
segmentation [GO:0035282],
intracellular signal transduction [GO:0035556],
convergent extension involved in organogenesis [GO:0060029],

Molecular Function:
frizzled binding [GO:0005109],
protein binding [GO:0005515],
protein kinase binding [GO:0019901],
protein domain specific binding [GO:0019904],
protein binding, bridging [GO:0030674],
identical protein binding [GO:0042802],
protein self-association [GO:0043621],
Rac GTPase binding [GO:0048365],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
aggresome [GO:0016235],
lateral plasma membrane [GO:0016328],
nuclear body [GO:0016604],
cytoplasmic vesicle [GO:0031410],
apical part of cell [GO:0045177],
clathrin-coated endocytic vesicle [GO:0045334],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
cell cortex [GO:0005938],
membrane [GO:0016020],
clathrin-coated vesicle [GO:0030136],