dual specificity phosphatase 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES
32029712 Primary synovial fibroblast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
16604064 HeLa Human NO

GO terms:

Biological Process:
inactivation of MAPK activity [GO:0000188],
dephosphorylation [GO:0016311],
negative regulation of cell migration [GO:0030336],
peptidyl-tyrosine dephosphorylation [GO:0035335],
negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059],
negative regulation of MAPK cascade [GO:0043409],
positive regulation of mitotic cell cycle [GO:0045931],
negative regulation of JNK cascade [GO:0046329],
negative regulation of T cell receptor signaling pathway [GO:0050860],
negative regulation of T cell activation [GO:0050868],
negative regulation of chemotaxis [GO:0050922],
regulation of focal adhesion assembly [GO:0051893],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
cellular response to epidermal growth factor stimulus [GO:0071364],
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264],
in utero embryonic development [GO:0001701],
protein dephosphorylation [GO:0006470],

Molecular Function:
protein tyrosine phosphatase activity [GO:0004725],
cytoskeletal protein binding [GO:0008092],
protein tyrosine/serine/threonine phosphatase activity [GO:0008138],
phosphatase activity [GO:0016791],
protein kinase binding [GO:0019901],
receptor tyrosine kinase binding [GO:0030971],
MAP kinase phosphatase activity [GO:0033549],
protein tyrosine kinase binding [GO:1990782],
phosphoprotein phosphatase activity [GO:0004721],
hydrolase activity [GO:0016787],

Cellular Component:
immunological synapse [GO:0001772],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],