DTX3L

deltex E3 ubiquitin ligase 3L

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31534052 Kidney Mouse YES
32029712 Primary synovial fibroblast Human YES

GO terms:

Biological Process:
protein polyubiquitination [GO:0000209],
positive regulation of defense response to virus by host [GO:0002230],
double-strand break repair [GO:0006302],
ubiquitin-dependent protein catabolic process [GO:0006511],
cellular response to DNA damage stimulus [GO:0006974],
Notch signaling pathway [GO:0007219],
endosome to lysosome transport [GO:0008333],
histone monoubiquitination [GO:0010390],
protein transport [GO:0015031],
viral process [GO:0016032],
protein ubiquitination [GO:0016567],
positive regulation of protein binding [GO:0032092],
histone H2A ubiquitination [GO:0033522],
histone H2B ubiquitination [GO:0033523],
positive regulation of chromatin binding [GO:0035563],
innate immune response [GO:0045087],
positive regulation of transcription, DNA-templated [GO:0045893],
negative regulation of ubiquitin-protein transferase activity [GO:0051444],
defense response to virus [GO:0051607],
protein autoubiquitination [GO:0051865],
protein K48-linked ubiquitination [GO:0070936],
positive regulation of protein localization to nucleus [GO:1900182],
positive regulation of NAD+ ADP-ribosyltransferase activity [GO:1901666],
positive regulation of protein localization to early endosome [GO:1902966],
positive regulation of receptor catabolic process [GO:2000646],
positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034],
immune system process [GO:0002376],
DNA repair [GO:0006281],
chromatin organization [GO:0006325],

Molecular Function:
ubiquitin-protein transferase activity [GO:0004842],
enzyme inhibitor activity [GO:0004857],
protein binding [GO:0005515],
enzyme activator activity [GO:0008047],
enzyme binding [GO:0019899],
histone binding [GO:0042393],
ubiquitin-like protein ligase binding [GO:0044389],
metal ion binding [GO:0046872],
ubiquitin protein ligase activity [GO:0061630],
STAT family protein binding [GO:0097677],
transferase activity [GO:0016740],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
lysosome [GO:0005764],
lysosomal membrane [GO:0005765],
early endosome [GO:0005769],
cytosol [GO:0005829],
early endosome membrane [GO:0031901],
macromolecular complex [GO:0032991],
endosome [GO:0005768],
membrane [GO:0016020],