DRD2

dopamine receptor D2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30988157 IMR-90 Human YES

GO terms:

Biological Process:
temperature homeostasis [GO:0001659],
response to hypoxia [GO:0001666],
negative regulation of protein phosphorylation [GO:0001933],
synaptic transmission, dopaminergic [GO:0001963],
response to amphetamine [GO:0001975],
neurological system process involved in regulation of systemic arterial blood pressure [GO:0001976],
regulation of heart rate [GO:0002027],
regulation of sodium ion transport [GO:0002028],
G-protein coupled receptor internalization [GO:0002031],
positive regulation of neuroblast proliferation [GO:0002052],
positive regulation of receptor internalization [GO:0002092],
autophagy [GO:0006914],
G-protein coupled receptor signaling pathway [GO:0007186],
adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188],
negative regulation of adenylate cyclase activity [GO:0007194],
adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195],
neuron-neuron synaptic transmission [GO:0007270],
axonogenesis [GO:0007409],
synapse assembly [GO:0007416],
sensory perception of smell [GO:0007608],
long-term memory [GO:0007616],
grooming behavior [GO:0007625],
locomotory behavior [GO:0007626],
adult walking behavior [GO:0007628],
protein localization [GO:0008104],
negative regulation of cell proliferation [GO:0008285],
associative learning [GO:0008306],
visual learning [GO:0008542],
response to light stimulus [GO:0009416],
response to iron ion [GO:0010039],
regulation of dopamine secretion [GO:0014059],
response to inactivity [GO:0014854],
Wnt signaling pathway [GO:0016055],
striatum development [GO:0021756],
orbitofrontal cortex development [GO:0021769],
cerebral cortex GABAergic interneuron migration [GO:0021853],
adenohypophysis development [GO:0021984],
negative regulation of cell migration [GO:0030336],
peristalsis [GO:0030432],
auditory behavior [GO:0031223],
activation of protein kinase activity [GO:0032147],
regulation of synaptic transmission, GABAergic [GO:0032228],
positive regulation of cytokinesis [GO:0032467],
circadian regulation of gene expression [GO:0032922],
negative regulation of dopamine secretion [GO:0033602],
response to histamine [GO:0034776],
response to nicotine [GO:0035094],
positive regulation of urine volume [GO:0035810],
positive regulation of renal sodium excretion [GO:0035815],
positive regulation of multicellular organism growth [GO:0040018],
response to cocaine [GO:0042220],
negative regulation of circadian sleep/wake cycle, sleep [GO:0042321],
dopamine metabolic process [GO:0042417],
response to drug [GO:0042493],
drinking behavior [GO:0042756],
regulation of potassium ion transport [GO:0043266],
response to morphine [GO:0043278],
pigmentation [GO:0043473],
regulation of phosphoprotein phosphatase activity [GO:0043666],
positive regulation of G-protein coupled receptor protein signaling pathway [GO:0045745],
negative regulation of blood pressure [GO:0045776],
negative regulation of innate immune response [GO:0045824],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
negative regulation of insulin secretion [GO:0046676],
behavioral response to cocaine [GO:0048148],
behavioral response to ethanol [GO:0048149],
regulation of long-term neuronal synaptic plasticity [GO:0048169],
response to axon injury [GO:0048678],
branching morphogenesis of a nerve [GO:0048755],
arachidonic acid secretion [GO:0050482],
negative regulation of protein secretion [GO:0050709],
release of sequestered calcium ion into cytosol [GO:0051209],
negative regulation of cytosolic calcium ion concentration [GO:0051481],
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482],
regulation of dopamine uptake involved in synaptic transmission [GO:0051584],
positive regulation of dopamine uptake involved in synaptic transmission [GO:0051586],
regulation of synapse structural plasticity [GO:0051823],
negative regulation of protein kinase B signaling [GO:0051898],
negative regulation of synaptic transmission, glutamatergic [GO:0051967],
excitatory postsynaptic potential [GO:0060079],
positive regulation of growth hormone secretion [GO:0060124],
prepulse inhibition [GO:0060134],
phospholipase C-activating dopamine receptor signaling pathway [GO:0060158],
negative regulation of dopamine receptor signaling pathway [GO:0060160],
negative regulation of cell death [GO:0060548],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880],
regulation of locomotion involved in locomotory behavior [GO:0090325],
positive regulation of glial cell-derived neurotrophic factor secretion [GO:1900168],
positive regulation of long-term synaptic potentiation [GO:1900273],
negative regulation of voltage-gated calcium channel activity [GO:1901386],
hyaloid vascular plexus regression [GO:1990384],
regulation of synaptic vesicle exocytosis [GO:2000300],
startle response [GO:0001964],
signal transduction [GO:0007165],
dopamine receptor signaling pathway [GO:0007212],
feeding behavior [GO:0007631],
adult behavior [GO:0030534],
forebrain development [GO:0030900],
intracellular signal transduction [GO:0035556],
regulation of MAPK cascade [GO:0043408],
acid secretion [GO:0046717],
positive regulation of neurogenesis [GO:0050769],
modulation of synaptic transmission [GO:0050804],
regulation of neurotransmitter uptake [GO:0051580],

Molecular Function:
dopamine neurotransmitter receptor activity, coupled via Gi/Go [GO:0001591],
G-protein coupled receptor activity [GO:0004930],
protein binding [GO:0005515],
drug binding [GO:0008144],
ionotropic glutamate receptor binding [GO:0035255],
identical protein binding [GO:0042802],
macromolecular complex binding [GO:0044877],
dopamine neurotransmitter receptor activity [GO:0004952],
receptor binding [GO:0005102],
dopamine binding [GO:0035240],

Cellular Component:
acrosomal vesicle [GO:0001669],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cilium [GO:0005929],
postsynaptic density [GO:0014069],
lateral plasma membrane [GO:0016328],
endocytic vesicle [GO:0030139],
axon [GO:0030424],
dendrite [GO:0030425],
sperm flagellum [GO:0036126],
dendritic spine [GO:0043197],
perikaryon [GO:0043204],
axon terminus [GO:0043679],
ciliary membrane [GO:0060170],
non-motile cilium [GO:0097730],
glutamatergic synapse [GO:0098978],
GABA-ergic synapse [GO:0098982],
integral component of postsynaptic membrane [GO:0099055],
integral component of presynaptic membrane [GO:0099056],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
synaptic vesicle membrane [GO:0030672],
cytoplasmic vesicle [GO:0031410],